Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital

 

Show simple item record

dc.contributor.author Mudau, Maanda en_ZA
dc.contributor.author Jacobson, Rachael en_ZA
dc.contributor.author Minenza, Nadia en_ZA
dc.contributor.author Kuonza, Lazarus en_ZA
dc.contributor.author Morris, Vida en_ZA
dc.contributor.author Engelbrecht, Heather en_ZA
dc.contributor.author Nicol, Mark P en_ZA
dc.contributor.author Bamford, Colleen en_ZA
dc.date.accessioned 2016-01-11T06:55:16Z
dc.date.available 2016-01-11T06:55:16Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Mudau, M., Jacobson, R., Minenza, N., Kuonza, L., Morris, V., Engelbrecht, H., ... & Bamford, C. (2013). Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital. PloS one, 8(3), e55985. doi:10.1371/journal.pone.0055985 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16298
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0055985
dc.description.abstract Objective: To describe an outbreak of multi-resistant Pseudomonas aeruginosa bloodstream infections (MRPA-BSI) that occurred in the haematology ward of a tertiary academic hospital in Cape Town, South Africa, and determine risk factors for acquisition of MRPA-BSI. METHODS: The outbreak investigation included a search for additional cases, review of patient records, environmental and staff screening, molecular typing using pulsed-field gel electrophoresis (PFGE) and Multi-locus sequencing (MLST) and a retrospective case-control study. RESULTS: Ten MRPA-BSI cases occurred in the haematology ward between January 2010 and January 2011. The case fatality rate was 80%. Staff screening specimens were negative for MRPA and an environmental source was not identified. PFGE showed that 9/10 isolates were related. MLST showed that 3 of these 9 isolates belonged to Sequence type (ST) 233 while the unrelated isolate belonged to ST260. CONCLUSION: We have described an outbreak of MRPA-BSI occurring over an extended period of time among neutropenic haematology patients. Molecular typing confirms that the outbreak was predominantly due to a single strain. The source of the outbreak was not identified, but the outbreak appears to have been controlled following intensive infection control measures. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Pseudomonas aeruginosa en_ZA
dc.subject.other Bloodstream infections en_ZA
dc.subject.other Hematology en_ZA
dc.subject.other Infectious disease control en_ZA
dc.subject.other Gram negative bacteria en_ZA
dc.subject.other Acute myeloid leukemia en_ZA
dc.subject.other Antibiotics en_ZA
dc.subject.other Nosocomial infections en_ZA
dc.title Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2013 Mudau et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Medical Biochemistry en_ZA
uct.type.filetype Text
uct.type.filetype Image


Files in this item

This item appears in the following Collection(s)

Show simple item record

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.