TB incidence in an adolescent cohort in South Africa

 

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dc.contributor.author Mahomed, Hassan en_ZA
dc.contributor.author Ehrlich, Rodney en_ZA
dc.contributor.author Hawkridge, Tony en_ZA
dc.contributor.author Hatherill, Mark en_ZA
dc.contributor.author Geiter, Lawrence en_ZA
dc.contributor.author Kafaar, Fazlin en_ZA
dc.contributor.author Abrahams, Deborah Ann en_ZA
dc.contributor.author Mulenga, Humphrey en_ZA
dc.contributor.author Tameris, Michele en_ZA
dc.contributor.author Geldenhuys, Hennie en_ZA
dc.date.accessioned 2016-01-02T05:08:39Z
dc.date.available 2016-01-02T05:08:39Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Mahomed, H., Ehrlich, R., Hawkridge, T., Hatherill, M., Geiter, L., Kafaar, F., ... & Hussey, G. D. (2013). TB incidence in an adolescent cohort in South Africa. PLoS One, 8(3), e59652. doi:10.1371/journal.pone.0059652 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16185
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0059652
dc.description.abstract BACKGROUND: Tuberculosis (TB) is a major public health problem globally. Little is known about TB incidence in adolescents who are a proposed target group for new TB vaccines. We conducted a study to determine the TB incidence rates and risk factors for TB disease in a cohort of school-going adolescents in a high TB burden area in South Africa. METHODS: We recruited adolescents aged 12 to 18 years from high schools in Worcester, South Africa. Demographic and clinical information was collected, a tuberculin skin test (TST) performed and blood drawn for a QuantiFERON TB Gold assay at baseline. Screening for TB cases occurred at follow up visits and by surveillance of registers at public sector TB clinics over a period of up to 3.8 years after enrolment. RESULTS: A total of 6,363 adolescents were enrolled (58% of the school population targeted). During follow up, 67 cases of bacteriologically confirmed TB were detected giving an overall incidence rate of 0.45 per 100 person years (95% confidence interval 0.29-0.72). Black or mixed race, maternal education of primary school or less or unknown, a positive baseline QuantiFERON assay and a positive baseline TST were significant predictors of TB disease on adjusted analysis. CONCLUSION: The adolescent TB incidence found in a high burden setting will help TB vaccine developers plan clinical trials in this population. Latent TB infection and low socio-economic status were predictors of TB disease. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Tuberculosis en_ZA
dc.subject.other Adolescents en_ZA
dc.subject.other Schools en_ZA
dc.subject.other Tuberculosis diagnosis and management en_ZA
dc.subject.other South Africa en_ZA
dc.subject.other Vaccines en_ZA
dc.subject.other Confidence intervals en_ZA
dc.subject.other Health risk analysis en_ZA
dc.title TB incidence in an adolescent cohort in South Africa en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2013 Mahomed et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Public Health and Family Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Mahomed, H., Ehrlich, R., Hawkridge, T., Hatherill, M., Geiter, L., Kafaar, F., ... Geldenhuys, H. (2013). TB incidence in an adolescent cohort in South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16185 en_ZA
dc.identifier.chicagocitation Mahomed, Hassan, Rodney Ehrlich, Tony Hawkridge, Mark Hatherill, Lawrence Geiter, Fazlin Kafaar, Deborah Ann Abrahams, Humphrey Mulenga, Michele Tameris, and Hennie Geldenhuys "TB incidence in an adolescent cohort in South Africa." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/16185 en_ZA
dc.identifier.vancouvercitation Mahomed H, Ehrlich R, Hawkridge T, Hatherill M, Geiter L, Kafaar F, et al. TB incidence in an adolescent cohort in South Africa. PLoS One. 2013; http://hdl.handle.net/11427/16185. en_ZA
dc.identifier.ris TY - Journal Article AU - Mahomed, Hassan AU - Ehrlich, Rodney AU - Hawkridge, Tony AU - Hatherill, Mark AU - Geiter, Lawrence AU - Kafaar, Fazlin AU - Abrahams, Deborah Ann AU - Mulenga, Humphrey AU - Tameris, Michele AU - Geldenhuys, Hennie AB - BACKGROUND: Tuberculosis (TB) is a major public health problem globally. Little is known about TB incidence in adolescents who are a proposed target group for new TB vaccines. We conducted a study to determine the TB incidence rates and risk factors for TB disease in a cohort of school-going adolescents in a high TB burden area in South Africa. METHODS: We recruited adolescents aged 12 to 18 years from high schools in Worcester, South Africa. Demographic and clinical information was collected, a tuberculin skin test (TST) performed and blood drawn for a QuantiFERON TB Gold assay at baseline. Screening for TB cases occurred at follow up visits and by surveillance of registers at public sector TB clinics over a period of up to 3.8 years after enrolment. RESULTS: A total of 6,363 adolescents were enrolled (58% of the school population targeted). During follow up, 67 cases of bacteriologically confirmed TB were detected giving an overall incidence rate of 0.45 per 100 person years (95% confidence interval 0.29-0.72). Black or mixed race, maternal education of primary school or less or unknown, a positive baseline QuantiFERON assay and a positive baseline TST were significant predictors of TB disease on adjusted analysis. CONCLUSION: The adolescent TB incidence found in a high burden setting will help TB vaccine developers plan clinical trials in this population. Latent TB infection and low socio-economic status were predictors of TB disease. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0059652 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - TB incidence in an adolescent cohort in South Africa TI - TB incidence in an adolescent cohort in South Africa UR - http://hdl.handle.net/11427/16185 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.