Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression

 

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dc.contributor.author Kader, Rehana en_ZA
dc.contributor.author Govender, Rajen en_ZA
dc.contributor.author Seedat, Soraya en_ZA
dc.contributor.author Koch, John Randy en_ZA
dc.contributor.author Parry, Charles en_ZA
dc.date.accessioned 2015-12-28T06:48:47Z
dc.date.available 2015-12-28T06:48:47Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Kader, R., Govender, R., Seedat, S., Koch, J. R., & Parry, C. (2014). Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. PloS one, 10(5), e0125088. doi:10.1371/journal.pone.0125088 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16058
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0125088
dc.description.abstract The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Alcoholism en_ZA
dc.subject.other Alcohol consumption en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Substance abuse en_ZA
dc.subject.other Drug adherence en_ZA
dc.subject.other Drug users en_ZA
dc.subject.other Drug abuse en_ZA
dc.subject.other South Africa en_ZA
dc.title Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2015 Kader et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Humanities en_ZA
dc.publisher.department Social Anthropology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Kader, R., Govender, R., Seedat, S., Koch, J. R., & Parry, C. (2015). Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. <i>PLoS One</i>, http://hdl.handle.net/11427/16058 en_ZA
dc.identifier.chicagocitation Kader, Rehana, Rajen Govender, Soraya Seedat, John Randy Koch, and Charles Parry "Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression." <i>PLoS One</i> (2015) http://hdl.handle.net/11427/16058 en_ZA
dc.identifier.vancouvercitation Kader R, Govender R, Seedat S, Koch JR, Parry C. Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. PLoS One. 2015; http://hdl.handle.net/11427/16058. en_ZA
dc.identifier.ris TY - Journal Article AU - Kader, Rehana AU - Govender, Rajen AU - Seedat, Soraya AU - Koch, John Randy AU - Parry, Charles AB - The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA. DA - 2015 DB - OpenUCT DO - 10.1371/journal.pone.0125088 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression TI - Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression UR - http://hdl.handle.net/11427/16058 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.