A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town

 

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dc.contributor.author Oni, Tolu en_ZA
dc.contributor.author Tsekela, Relebohile en_ZA
dc.contributor.author Kwaza, Bekekile en_ZA
dc.contributor.author Manjezi, Lulama en_ZA
dc.contributor.author Bangani, Nonzwakazi en_ZA
dc.contributor.author Wilkinson, Katalin A en_ZA
dc.contributor.author Coetzee, David en_ZA
dc.contributor.author Wilkinson, Robert J en_ZA
dc.date.accessioned 2015-12-28T06:47:45Z
dc.date.available 2015-12-28T06:47:45Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Oni, T., Tsekela, R., Kwaza, B., Manjezi, L., Bangani, N., Wilkinson, K. A., ... & Wilkinson, R. J. (2012). A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town. PLoS ONE, 7(12), e52489. doi:10.1371/journal.pone.0052489 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16048
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0052489
dc.description.abstract Introduction: Despite high rates of successful treatment TB incidence in South Africa remains high, suggesting ongoing transmission and a large reservoir of latently infected persons. Isoniazid preventive therapy (IPT) is recommended as preventive therapy in HIV-infected persons. However, implementation has been slow, impeded by barriers and challenges including the fear of non-adherence. Objective and Methods: The aim was to evaluate predictors of IPT non-completion. One hundred and sixty four antiretroviral therapy (ART)-naïve HIV-infected patients with tuberculin skin test ≥5 mm were recruited from Khayelitsha day hospital and followed up monthly. A questionnaire was used to collect demographic information. Results: The overall completion rate was 69%. In multivariable analysis, there was a 29% decrease in risk of non-completion for every year after HIV diagnosis (OR 0.81; 95% C.I. 0.68–0.98). Self-reported alcohol drinkers (OR 4.05; 95% C.I. 1.89–9.06) also had a four-fold higher risk of non-completion, with a strong association between alcohol drinkers and smoking (χ2 27.08; p<0.001). Conclusion: We identify patients with a recent HIV diagnosis, in addition to self-reported drinkers and smokers as being at higher risk of non-completion of IPT. The period of time since HIV diagnosis should therefore be taken into account when initiating IPT. Our results also suggest that smokers and alcohol drinkers should be identified and targeted for adherence interventions when implementing IPT on a wider scale. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other HIV diagnosis and management en_ZA
dc.subject.other Alcohol consumption en_ZA
dc.subject.other Tuberculosis en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Antiretroviral therapy en_ZA
dc.subject.other Tuberculosis diagnosis and management en_ZA
dc.subject.other Isoniazid en_ZA
dc.subject.other South Africa en_ZA
dc.title A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2012 Oni et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Oni, T., Tsekela, R., Kwaza, B., Manjezi, L., Bangani, N., Wilkinson, K. A., ... Wilkinson, R. J. (2012). A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town. <i>PLoS One</i>, http://hdl.handle.net/11427/16048 en_ZA
dc.identifier.chicagocitation Oni, Tolu, Relebohile Tsekela, Bekekile Kwaza, Lulama Manjezi, Nonzwakazi Bangani, Katalin A Wilkinson, David Coetzee, and Robert J Wilkinson "A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town." <i>PLoS One</i> (2012) http://hdl.handle.net/11427/16048 en_ZA
dc.identifier.vancouvercitation Oni T, Tsekela R, Kwaza B, Manjezi L, Bangani N, Wilkinson KA, et al. A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town. PLoS One. 2012; http://hdl.handle.net/11427/16048. en_ZA
dc.identifier.ris TY - Journal Article AU - Oni, Tolu AU - Tsekela, Relebohile AU - Kwaza, Bekekile AU - Manjezi, Lulama AU - Bangani, Nonzwakazi AU - Wilkinson, Katalin A AU - Coetzee, David AU - Wilkinson, Robert J AB - Introduction: Despite high rates of successful treatment TB incidence in South Africa remains high, suggesting ongoing transmission and a large reservoir of latently infected persons. Isoniazid preventive therapy (IPT) is recommended as preventive therapy in HIV-infected persons. However, implementation has been slow, impeded by barriers and challenges including the fear of non-adherence. Objective and Methods: The aim was to evaluate predictors of IPT non-completion. One hundred and sixty four antiretroviral therapy (ART)-naïve HIV-infected patients with tuberculin skin test ≥5 mm were recruited from Khayelitsha day hospital and followed up monthly. A questionnaire was used to collect demographic information. Results: The overall completion rate was 69%. In multivariable analysis, there was a 29% decrease in risk of non-completion for every year after HIV diagnosis (OR 0.81; 95% C.I. 0.68–0.98). Self-reported alcohol drinkers (OR 4.05; 95% C.I. 1.89–9.06) also had a four-fold higher risk of non-completion, with a strong association between alcohol drinkers and smoking (χ2 27.08; p<0.001). Conclusion: We identify patients with a recent HIV diagnosis, in addition to self-reported drinkers and smokers as being at higher risk of non-completion of IPT. The period of time since HIV diagnosis should therefore be taken into account when initiating IPT. Our results also suggest that smokers and alcohol drinkers should be identified and targeted for adherence interventions when implementing IPT on a wider scale. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pone.0052489 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town TI - A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town UR - http://hdl.handle.net/11427/16048 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.