Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambar�n�, Gabon

 

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dc.contributor.author Janssen, Saskia en_ZA
dc.contributor.author Hermans, Sabine en_ZA
dc.contributor.author Knap, Martijn en_ZA
dc.contributor.author Moekotte, Alma en_ZA
dc.contributor.author Rossatanga, Elie G en_ZA
dc.contributor.author Adegnika, Akim A en_ZA
dc.contributor.author Bélard, Sabine en_ZA
dc.contributor.author Hänscheid, Thomas en_ZA
dc.contributor.author Grobusch, Martin P en_ZA
dc.date.accessioned 2015-12-28T06:47:33Z
dc.date.available 2015-12-28T06:47:33Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Janssen, S., Hermans, S., Knap, M., Moekotte, A., Rossatanga, E. G., Adegnika, A. A., ... & Grobusch, M. P. (2015). Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambarene, Gabon. PLoS neglected tropical diseases, 9(5), e0003769. doi:10.1371/journal.pntd.0003769 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16033
dc.identifier.uri http://dx.doi.org/10.1371/journal.pntd.0003769
dc.description.abstract Background: Foci of the HIV epidemic and helminthic infections largely overlap geographically. Treatment options for helminth infections are limited, and there is a paucity of drug-development research in this area. Limited evidence suggests that antiretroviral therapy (ART) reduces prevalence of helminth infections in HIV-infected individuals. We investigated whether ART exposure and cotrimoxazole preventive therapy (CTX-P) is associated with a reduced prevalence of helminth infections. Methodology and Principal Findings: This cross-sectional study was conducted at a primary HIV-clinic in Lambaréné, Gabon. HIV-infected adults who were ART-naïve or exposed to ART for at least 3 months submitted one blood sample and stool and urine samples on 3 consecutive days. Outcome was helminth infection with intestinal helminths, Schistosoma haematobium, Loa loa or Mansonella perstans. Multivariable logistic regression was used to assess associations between ART or CTX-P and helminth infection. In total, 408 patients were enrolled. Helminth infection was common (77/252 [30.5%]). Filarial infections were most prevalent (55/310 [17.7%]), followed by infection with intestinal helminths (35/296 [11.8%]) and S. haematobium (19/323 [5.9%]). Patients on CTX-P had a reduced risk of Loa loa microfilaremia (adjusted odds ratio (aOR) 0.47, 95% CI 0.23-0.97, P = 0.04), also in the subgroup of patients on ART (aOR 0.36, 95% CI 0.13-0.96, P = 0.04). There was no effect of ART exposure on helminth infection prevalence. Conclusions/Significance: CTX-P use was associated with a decreased risk of Loa loa infection, suggesting an anthelminthic effect of antifolate drugs. No relation between ART use and helminth infections was established. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLOS Neglected Tropical Diseases en_ZA
dc.source.uri http://journals.plos.org/plosntds en_ZA
dc.subject.other Helminth infections en_ZA
dc.subject.other Helminths en_ZA
dc.subject.other Gastrointestinal tract en_ZA
dc.subject.other Loa loa en_ZA
dc.subject.other Antiretroviral therapy en_ZA
dc.subject.other Schistosoma haematobium en_ZA
dc.subject.other Urine en_ZA
dc.subject.other Drug interactions en_ZA
dc.title Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambar�n�, Gabon en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2015 Janssen et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Janssen, S., Hermans, S., Knap, M., Moekotte, A., Rossatanga, E. G., Adegnika, A. A., ... Grobusch, M. P. (2015). Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambar�n�, Gabon. <i>PLOS Neglected Tropical Diseases</i>, http://hdl.handle.net/11427/16033 en_ZA
dc.identifier.chicagocitation Janssen, Saskia, Sabine Hermans, Martijn Knap, Alma Moekotte, Elie G Rossatanga, Akim A Adegnika, Sabine Bélard, Thomas Hänscheid, and Martin P Grobusch "Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambar�n�, Gabon." <i>PLOS Neglected Tropical Diseases</i> (2015) http://hdl.handle.net/11427/16033 en_ZA
dc.identifier.vancouvercitation Janssen S, Hermans S, Knap M, Moekotte A, Rossatanga EG, Adegnika AA, et al. Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambar�n�, Gabon. PLOS Neglected Tropical Diseases. 2015; http://hdl.handle.net/11427/16033. en_ZA
dc.identifier.ris TY - Journal Article AU - Janssen, Saskia AU - Hermans, Sabine AU - Knap, Martijn AU - Moekotte, Alma AU - Rossatanga, Elie G AU - Adegnika, Akim A AU - Bélard, Sabine AU - Hänscheid, Thomas AU - Grobusch, Martin P AB - Background: Foci of the HIV epidemic and helminthic infections largely overlap geographically. Treatment options for helminth infections are limited, and there is a paucity of drug-development research in this area. Limited evidence suggests that antiretroviral therapy (ART) reduces prevalence of helminth infections in HIV-infected individuals. We investigated whether ART exposure and cotrimoxazole preventive therapy (CTX-P) is associated with a reduced prevalence of helminth infections. Methodology and Principal Findings: This cross-sectional study was conducted at a primary HIV-clinic in Lambaréné, Gabon. HIV-infected adults who were ART-naïve or exposed to ART for at least 3 months submitted one blood sample and stool and urine samples on 3 consecutive days. Outcome was helminth infection with intestinal helminths, Schistosoma haematobium, Loa loa or Mansonella perstans. Multivariable logistic regression was used to assess associations between ART or CTX-P and helminth infection. In total, 408 patients were enrolled. Helminth infection was common (77/252 [30.5%]). Filarial infections were most prevalent (55/310 [17.7%]), followed by infection with intestinal helminths (35/296 [11.8%]) and S. haematobium (19/323 [5.9%]). Patients on CTX-P had a reduced risk of Loa loa microfilaremia (adjusted odds ratio (aOR) 0.47, 95% CI 0.23-0.97, P = 0.04), also in the subgroup of patients on ART (aOR 0.36, 95% CI 0.13-0.96, P = 0.04). There was no effect of ART exposure on helminth infection prevalence. Conclusions/Significance: CTX-P use was associated with a decreased risk of Loa loa infection, suggesting an anthelminthic effect of antifolate drugs. No relation between ART use and helminth infections was established. DA - 2015 DB - OpenUCT DO - 10.1371/journal.pntd.0003769 DP - University of Cape Town J1 - PLOS Neglected Tropical Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambar�n�, Gabon TI - Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambar�n�, Gabon UR - http://hdl.handle.net/11427/16033 ER - en_ZA


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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited