dc.contributor.author |
Mlisana, Koleka
|
en_ZA |
dc.contributor.author |
Auld, Sara C
|
en_ZA |
dc.contributor.author |
Grobler, Anneke
|
en_ZA |
dc.contributor.author |
Loggerenberg, Francois van
|
en_ZA |
dc.contributor.author |
Williamson, Carolyn
|
en_ZA |
dc.contributor.author |
Iriogbe, Itua
|
en_ZA |
dc.contributor.author |
Sobieszczyk, Magdalena E
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en_ZA |
dc.contributor.author |
Karim, Salim S Abdool
|
en_ZA |
dc.contributor.author |
Team, for the CAPRISA Acute Infection Study
|
en_ZA |
dc.date.accessioned |
2015-12-28T06:47:29Z |
|
dc.date.available |
2015-12-28T06:47:29Z |
|
dc.date.issued |
2008 |
en_ZA |
dc.identifier.citation |
Mlisana, K., Auld, S. C., Grobler, A., Van Loggerenberg, F., Williamson, C., Iriogbe, I., ... & Karim, S. A. (2008). Anaemia in acute HIV-1 subtype C infection. PloS one, 3(2), e1626. doi:10.1371/journal.pone.0001626 |
en_ZA |
dc.identifier.uri |
http://hdl.handle.net/11427/16029
|
|
dc.identifier.uri |
http://dx.doi.org/10.1371/journal.pone.0001626
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|
dc.description.abstract |
BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early HIV-1 infection. METHODS: HIV-negative women (n = 245) were enrolled into an observational cohort as part of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) Acute Infection Study. Acute infection was diagnosed following a positive HIV RNA PCR in the absence of antibodies, or detection of HIV-1 antibodies within 3 months of a previously negative antibody test. Haemotologic parameters were assessed before infection and at regular intervals in the first twelve months of HIV infection. RESULTS: Fifty-seven participants with acute HIV infection were identified at a median of 14.5 days post-infection (range 10-81) and were enrolled in the CAPRISA Acute Infection cohort at a median of 41 days post-infection (range 15-104). Mean haemoglobin prior to HIV-1 infection was 12.7 g/dL, with a mean decline of 0.46 g/dL following infection. The prevalence of anaemia increased from 25.0% prior to HIV-1 infection to 52.6% at 3 months post-infection, 61.1% at 6 months post-infection, and 51.4% at 12 months post-infection. CONCLUSIONS: Haematologic derangements and anaemia with a trend towards iron deficiency are common with acute HIV-1 subtype C infection in this small cohort. The negative impact of anaemia concurrent with established HIV infection upon morbidity and mortality has been well documented but the prognostic potential and long-term effects of anaemia during acute HIV-1 infection remain unknown. |
en_ZA |
dc.language.iso |
eng |
en_ZA |
dc.publisher |
Public Library of Science |
en_ZA |
dc.rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
en_ZA |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0 |
en_ZA |
dc.source |
PLoS One |
en_ZA |
dc.source.uri |
http://journals.plos.org/plosone
|
en_ZA |
dc.subject.other |
Anemia |
en_ZA |
dc.subject.other |
HIV-1 |
en_ZA |
dc.subject.other |
HIV infections |
en_ZA |
dc.subject.other |
Antibodies |
en_ZA |
dc.subject.other |
Viral load |
en_ZA |
dc.subject.other |
Enzyme-linked immunoassays |
en_ZA |
dc.subject.other |
Ferritin |
en_ZA |
dc.subject.other |
AIDS |
en_ZA |
dc.title |
Anaemia in acute HIV-1 subtype C infection |
en_ZA |
dc.type |
Journal Article |
en_ZA |
dc.rights.holder |
© 2008 Mlisana et al |
en_ZA |
uct.type.publication |
Research |
en_ZA |
uct.type.resource |
Article
|
en_ZA |
dc.publisher.institution |
University of Cape Town |
|
dc.publisher.faculty |
Faculty of Health Sciences |
en_ZA |
dc.publisher.department |
Institute of Infectious Disease and Molecular Medicine |
en_ZA |
uct.type.filetype |
Text |
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uct.type.filetype |
Image |
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dc.identifier.apacitation |
Mlisana, K., Auld, S. C., Grobler, A., Loggerenberg, F. v., Williamson, C., Iriogbe, I., ... Team, f. t. C. A. I. S. (2008). Anaemia in acute HIV-1 subtype C infection. <i>PLoS One</i>, http://hdl.handle.net/11427/16029 |
en_ZA |
dc.identifier.chicagocitation |
Mlisana, Koleka, Sara C Auld, Anneke Grobler, Francois van Loggerenberg, Carolyn Williamson, Itua Iriogbe, Magdalena E Sobieszczyk, Salim S Abdool Karim, and for the CAPRISA Acute Infection Study Team "Anaemia in acute HIV-1 subtype C infection." <i>PLoS One</i> (2008) http://hdl.handle.net/11427/16029 |
en_ZA |
dc.identifier.vancouvercitation |
Mlisana K, Auld SC, Grobler A, Loggerenberg Fv, Williamson C, Iriogbe I, et al. Anaemia in acute HIV-1 subtype C infection. PLoS One. 2008; http://hdl.handle.net/11427/16029. |
en_ZA |
dc.identifier.ris |
TY - Journal Article
AU - Mlisana, Koleka
AU - Auld, Sara C
AU - Grobler, Anneke
AU - Loggerenberg, Francois van
AU - Williamson, Carolyn
AU - Iriogbe, Itua
AU - Sobieszczyk, Magdalena E
AU - Karim, Salim S Abdool
AU - Team, for the CAPRISA Acute Infection Study
AB - BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early HIV-1 infection. METHODS: HIV-negative women (n = 245) were enrolled into an observational cohort as part of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) Acute Infection Study. Acute infection was diagnosed following a positive HIV RNA PCR in the absence of antibodies, or detection of HIV-1 antibodies within 3 months of a previously negative antibody test. Haemotologic parameters were assessed before infection and at regular intervals in the first twelve months of HIV infection. RESULTS: Fifty-seven participants with acute HIV infection were identified at a median of 14.5 days post-infection (range 10-81) and were enrolled in the CAPRISA Acute Infection cohort at a median of 41 days post-infection (range 15-104). Mean haemoglobin prior to HIV-1 infection was 12.7 g/dL, with a mean decline of 0.46 g/dL following infection. The prevalence of anaemia increased from 25.0% prior to HIV-1 infection to 52.6% at 3 months post-infection, 61.1% at 6 months post-infection, and 51.4% at 12 months post-infection. CONCLUSIONS: Haematologic derangements and anaemia with a trend towards iron deficiency are common with acute HIV-1 subtype C infection in this small cohort. The negative impact of anaemia concurrent with established HIV infection upon morbidity and mortality has been well documented but the prognostic potential and long-term effects of anaemia during acute HIV-1 infection remain unknown.
DA - 2008
DB - OpenUCT
DO - 10.1371/journal.pone.0001626
DP - University of Cape Town
J1 - PLoS One
LK - https://open.uct.ac.za
PB - University of Cape Town
PY - 2008
T1 - Anaemia in acute HIV-1 subtype C infection
TI - Anaemia in acute HIV-1 subtype C infection
UR - http://hdl.handle.net/11427/16029
ER -
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en_ZA |