Anaemia in acute HIV-1 subtype C infection

 

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dc.contributor.author Mlisana, Koleka en_ZA
dc.contributor.author Auld, Sara C en_ZA
dc.contributor.author Grobler, Anneke en_ZA
dc.contributor.author Loggerenberg, Francois van en_ZA
dc.contributor.author Williamson, Carolyn en_ZA
dc.contributor.author Iriogbe, Itua en_ZA
dc.contributor.author Sobieszczyk, Magdalena E en_ZA
dc.contributor.author Karim, Salim S Abdool en_ZA
dc.contributor.author Team, for the CAPRISA Acute Infection Study en_ZA
dc.date.accessioned 2015-12-28T06:47:29Z
dc.date.available 2015-12-28T06:47:29Z
dc.date.issued 2008 en_ZA
dc.identifier.citation Mlisana, K., Auld, S. C., Grobler, A., Van Loggerenberg, F., Williamson, C., Iriogbe, I., ... & Karim, S. A. (2008). Anaemia in acute HIV-1 subtype C infection. PloS one, 3(2), e1626. doi:10.1371/journal.pone.0001626 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16029
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0001626
dc.description.abstract BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early HIV-1 infection. METHODS: HIV-negative women (n = 245) were enrolled into an observational cohort as part of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) Acute Infection Study. Acute infection was diagnosed following a positive HIV RNA PCR in the absence of antibodies, or detection of HIV-1 antibodies within 3 months of a previously negative antibody test. Haemotologic parameters were assessed before infection and at regular intervals in the first twelve months of HIV infection. RESULTS: Fifty-seven participants with acute HIV infection were identified at a median of 14.5 days post-infection (range 10-81) and were enrolled in the CAPRISA Acute Infection cohort at a median of 41 days post-infection (range 15-104). Mean haemoglobin prior to HIV-1 infection was 12.7 g/dL, with a mean decline of 0.46 g/dL following infection. The prevalence of anaemia increased from 25.0% prior to HIV-1 infection to 52.6% at 3 months post-infection, 61.1% at 6 months post-infection, and 51.4% at 12 months post-infection. CONCLUSIONS: Haematologic derangements and anaemia with a trend towards iron deficiency are common with acute HIV-1 subtype C infection in this small cohort. The negative impact of anaemia concurrent with established HIV infection upon morbidity and mortality has been well documented but the prognostic potential and long-term effects of anaemia during acute HIV-1 infection remain unknown. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Anemia en_ZA
dc.subject.other HIV-1 en_ZA
dc.subject.other HIV infections en_ZA
dc.subject.other Antibodies en_ZA
dc.subject.other Viral load en_ZA
dc.subject.other Enzyme-linked immunoassays en_ZA
dc.subject.other Ferritin en_ZA
dc.subject.other AIDS en_ZA
dc.title Anaemia in acute HIV-1 subtype C infection en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2008 Mlisana et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.