The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa

 

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dc.contributor.author Mahomed, Hassan en_ZA
dc.contributor.author Hawkridge, Tony en_ZA
dc.contributor.author Verver, Suzanne en_ZA
dc.contributor.author Abrahams, Deborah en_ZA
dc.contributor.author Geiter, Lawrence en_ZA
dc.contributor.author Hatherill, Mark en_ZA
dc.contributor.author Ehrlich, Rodney en_ZA
dc.contributor.author Hanekom, Willem A en_ZA
dc.contributor.author Hussey, Gregory D en_ZA
dc.date.accessioned 2015-12-20T16:04:43Z
dc.date.available 2015-12-20T16:04:43Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Mahomed, H., Hawkridge, T., Verver, S., Abrahams, D., Geiter, L., Hatherill, M., ... & Hussey, G. D. (2011). The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. PLoS One, 6(3), e17984. doi:10.1371/journal.pone.0017984 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15914
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0017984
dc.description.abstract Setting This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000. Main Objective To compare the predictive value of a baseline tuberculin skin test (TST) with that of the QuantiFERON TB Gold (In-tube) assay (QFT) for subsequent microbiologically confirmed TB disease among adolescents. METHODS: Adolescents aged 12-18 years were recruited from high schools in the study area. At baseline, blood was drawn for QFT and a TST administered. Participants were followed up for up to 3.8 years for incident TB disease (median 2.4 years). RESULTS: After exclusions, 5244 (82.4%) of 6,363 adolescents enrolled, were analysed. The TB incidence rate was 0.60 cases per 100 person years (pyrs) (95% CI 0.43-0.82) for baseline TST positive (≥5 mm) participants and 0.64 cases per 100 pyrs (95% CI 0.45-0.87) for baseline QFT positive participants. TB incidence rates were 0.22 per 100 pyrs (0.11-0.39) and 0.22 per 100 pyrs (0.12-0.38) among those with a negative baseline TST and QFT respectively. Sensitivity for incident TB disease was 76.9% for TST and 75.0% for QFT (p = 0.81). Positive predictive value was 1.4% for TST and 1.5% for QFT. CONCLUSION: Positive TST and QFT tests were moderately sensitive predictors of progression to microbiologically confirmed TB disease. There was no significant difference in the predictive ability of these tests for TB disease amongst adolescents in this high burden setting. Therefore, these findings do not support use of QFT in preference to TST to predict the risk of TB disease in this study population. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Tuberculosis en_ZA
dc.subject.other Adolescents en_ZA
dc.subject.other Tuberculosis diagnosis and management en_ZA
dc.subject.other Mycobacterium tuberculosis en_ZA
dc.subject.other History of tuberculosis en_ZA
dc.subject.other Sputum en_ZA
dc.subject.other Cohort studies en_ZA
dc.subject.other Tuberculin en_ZA
dc.title The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2011 Mahomed et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department South African Tuberculosis Vaccine Initiative (SATVI) en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Mahomed, H., Hawkridge, T., Verver, S., Abrahams, D., Geiter, L., Hatherill, M., ... Hussey, G. D. (2011). The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/15914 en_ZA
dc.identifier.chicagocitation Mahomed, Hassan, Tony Hawkridge, Suzanne Verver, Deborah Abrahams, Lawrence Geiter, Mark Hatherill, Rodney Ehrlich, Willem A Hanekom, and Gregory D Hussey "The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa." <i>PLoS One</i> (2011) http://hdl.handle.net/11427/15914 en_ZA
dc.identifier.vancouvercitation Mahomed H, Hawkridge T, Verver S, Abrahams D, Geiter L, Hatherill M, et al. The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. PLoS One. 2011; http://hdl.handle.net/11427/15914. en_ZA
dc.identifier.ris TY - Journal Article AU - Mahomed, Hassan AU - Hawkridge, Tony AU - Verver, Suzanne AU - Abrahams, Deborah AU - Geiter, Lawrence AU - Hatherill, Mark AU - Ehrlich, Rodney AU - Hanekom, Willem A AU - Hussey, Gregory D AB - Setting This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000. Main Objective To compare the predictive value of a baseline tuberculin skin test (TST) with that of the QuantiFERON TB Gold (In-tube) assay (QFT) for subsequent microbiologically confirmed TB disease among adolescents. METHODS: Adolescents aged 12-18 years were recruited from high schools in the study area. At baseline, blood was drawn for QFT and a TST administered. Participants were followed up for up to 3.8 years for incident TB disease (median 2.4 years). RESULTS: After exclusions, 5244 (82.4%) of 6,363 adolescents enrolled, were analysed. The TB incidence rate was 0.60 cases per 100 person years (pyrs) (95% CI 0.43-0.82) for baseline TST positive (≥5 mm) participants and 0.64 cases per 100 pyrs (95% CI 0.45-0.87) for baseline QFT positive participants. TB incidence rates were 0.22 per 100 pyrs (0.11-0.39) and 0.22 per 100 pyrs (0.12-0.38) among those with a negative baseline TST and QFT respectively. Sensitivity for incident TB disease was 76.9% for TST and 75.0% for QFT (p = 0.81). Positive predictive value was 1.4% for TST and 1.5% for QFT. CONCLUSION: Positive TST and QFT tests were moderately sensitive predictors of progression to microbiologically confirmed TB disease. There was no significant difference in the predictive ability of these tests for TB disease amongst adolescents in this high burden setting. Therefore, these findings do not support use of QFT in preference to TST to predict the risk of TB disease in this study population. DA - 2011 DB - OpenUCT DO - 10.1371/journal.pone.0017984 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa TI - The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa UR - http://hdl.handle.net/11427/15914 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.