Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population

 

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dc.contributor.advisor Lubbe, Darlene en_ZA
dc.contributor.author Monteiro, Pedro Vilas Boas en_ZA
dc.date.accessioned 2015-12-10T09:30:15Z
dc.date.available 2015-12-10T09:30:15Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Monteiro, P. 2015. Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15753
dc.description.abstract Statement of problem: Topical corticosteroids nasal sprays remain first line of treatment for patients with chronic rhinosinusitis (with or without nasal polyps). The main aim of treatment is to improve nasal symptoms by reducing or eliminating the nasal polyps and preventing polyp recurrence post-operatively. Our aims were to determine if the type of corticosteroid nasal spray used post operatively influences polyp recurrence rate and if there were any subsequent economic implications as we only have beclomethasone available for prescription in our state hospital. Methods: Retrospective case note review of all Samter's patients who underwent fronto-spheno-ethmoidectomy by a single surgeon (2000 – 2014). Results: 58 patients were included in our study, divided into 3 study groups. When compared to patients using beclomethasone; patients using fluticasone had an 80% reduced risk of polyp recurrence and patients using mometasone a 90% reduced risk. This rose to 88% and 96% respectively when adjusted for age. Conclusion: Fluticasone and mometasone are both statistically significantly more effective at reducing polyp recurrence than beclomethasone in our population group. Mometasone appeared more effective than fluticasone, but this difference was not statistically significant. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Otorhinolaryngology en_ZA
dc.title Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Otorhinolaryngology en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MMed en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Monteiro, P. V. B. (2015). <i>Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Otorhinolaryngology. Retrieved from http://hdl.handle.net/11427/15753 en_ZA
dc.identifier.chicagocitation Monteiro, Pedro Vilas Boas. <i>"Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Otorhinolaryngology, 2015. http://hdl.handle.net/11427/15753 en_ZA
dc.identifier.vancouvercitation Monteiro PVB. Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Otorhinolaryngology, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/15753 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Monteiro, Pedro Vilas Boas AB - Statement of problem: Topical corticosteroids nasal sprays remain first line of treatment for patients with chronic rhinosinusitis (with or without nasal polyps). The main aim of treatment is to improve nasal symptoms by reducing or eliminating the nasal polyps and preventing polyp recurrence post-operatively. Our aims were to determine if the type of corticosteroid nasal spray used post operatively influences polyp recurrence rate and if there were any subsequent economic implications as we only have beclomethasone available for prescription in our state hospital. Methods: Retrospective case note review of all Samter's patients who underwent fronto-spheno-ethmoidectomy by a single surgeon (2000 – 2014). Results: 58 patients were included in our study, divided into 3 study groups. When compared to patients using beclomethasone; patients using fluticasone had an 80% reduced risk of polyp recurrence and patients using mometasone a 90% reduced risk. This rose to 88% and 96% respectively when adjusted for age. Conclusion: Fluticasone and mometasone are both statistically significantly more effective at reducing polyp recurrence than beclomethasone in our population group. Mometasone appeared more effective than fluticasone, but this difference was not statistically significant. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population TI - Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population UR - http://hdl.handle.net/11427/15753 ER - en_ZA


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