Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype

 

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dc.contributor.advisor Egan, Timothy J en_ZA
dc.contributor.advisor Hunter, Roger en_ZA
dc.contributor.author Mvumvu, Nomakhwezi en_ZA
dc.date.accessioned 2015-12-09T14:47:09Z
dc.date.available 2015-12-09T14:47:09Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Mvumvu, N. 2015. Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15743
dc.description.abstract The blood stage of the malarial parasite life-cycle is a vital stage that is believed to be a target for most antimalarial drugs. It is in this stage that host haemoglobin is degraded to provide nutrients for the survival of the parasite. However, a pathway (known as the haem detoxification pathway) that gives rise to the unique, microcrystalline ferriprotoporphryin IX [Fe(III)PPIX] dimer called haemozoin as an end-product, also arises as a result of the degradation. This haem detoxification pathway is a principal target for some of these antimalarials, especially those that contain the quinoline scaffold (e.g chloroquine), and has yielded outstanding results for the antimalarial drug discovery and development world. Even so, the spread of parasite resistance among these drugs has rendered most ineffective, resulting in a need for new scaffolds to target the pathway. However, the mode of action of chloroquine on haem may still be used as a model for identification of hits from these new scaffolds. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image


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