The histone H1 of the sea urchin embryo, partial structures, enzymatic modifactions and developmental programme

 

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dc.contributor.advisor Von Holt, Claus en_ZA
dc.contributor.advisor Strickland, W N en_ZA
dc.contributor.author De Groot, Petronella Christina en_ZA
dc.date.accessioned 2015-12-08T06:56:45Z
dc.date.available 2015-12-08T06:56:45Z
dc.date.issued 1982 en_ZA
dc.identifier.citation De Groot, P. 1982. The histone H1 of the sea urchin embryo, partial structures, enzymatic modifactions and developmental programme. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15667
dc.description Bibliography: leaves 207-233. en_ZA
dc.description.abstract Developmental biology owes a tremendous debt to sea urchins. These animals have proved to be experimental jewels, and since they are distributed abundantly along the Peninsula coastline, they are readily at hand. Sea urchin embryos have been shown to be extremely well suited for analysis of developmental processes at the ultrastructural, biochemical and molecular levels. This project is a study of the very lysine-rich histone fraction or H1-histone fraction of Parechinus angulosus embryo. The first part deals with the characterization and separation of the H1-variants present in the late gastrula embryo. The second part describes the determination of the partial primary structure of the three chromatographically separated H1-fractions: The amino acid composition and sequences of the H1-histone variants are compared to those of H1-histones from other sea urchin embryo species and from various other sources. The third part is a study of the histone variant synthesis program during the early development. [3H] Lysine incorporation into newly synthesized histones was utilized to examine the histone synthetic program. This part also describes the examination of histone acetylation and phosphorylation occurring during the ninth cell cycle of development. Examination of the modification of the different histone variants and modifications of the histone variants at the different cell stages are discussed. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Biochemistry en_ZA
dc.title The histone H1 of the sea urchin embryo, partial structures, enzymatic modifactions and developmental programme en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Molecular and Cell Biology en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image


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