Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study

 

Show simple item record

dc.contributor.author Polman, Katja en_ZA
dc.contributor.author Becker, Soren en_ZA
dc.contributor.author Alirol, Emilie en_ZA
dc.contributor.author Bhatta, Nisha en_ZA
dc.contributor.author Bhattarai, Narayan en_ZA
dc.contributor.author Bottieau, Emmanuel en_ZA
dc.contributor.author Bratschi, Martin en_ZA
dc.contributor.author Burza, Sakib en_ZA
dc.contributor.author Coulibaly, Jean en_ZA
dc.contributor.author Doumbia, Mama en_ZA
dc.contributor.author Horie, Ninon en_ZA
dc.contributor.author Jacobs, Jan en_ZA
dc.contributor.author Khanal, Basudha en_ZA
dc.contributor.author Landoure, Aly en_ZA
dc.contributor.author Mahendradhata, Yodi en_ZA
dc.contributor.author Meheu en_ZA
dc.date.accessioned 2015-12-07T08:53:18Z
dc.date.available 2015-12-07T08:53:18Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Polman, K., Becker, S. L., Alirol, E., Bhatta, N. K., Bhattarai, N. R., Bottieau, E., ... & Utzinger, J. (2015). Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain≥ 14 days): Pierrea multi-country, prospective, non-experimental case–control study. BMC infectious diseases, 15(1), 338. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15663
dc.identifier.uri http://dx.doi.org/10.1186/s12879-015-1074-x
dc.description.abstract BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14days), the spectrum of pathogens that may give rise to persistent diarrhoea ([greater than or equal to]14days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.METHODS/DESIGN:This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea ([greater than or equal to]14days; in individuals aged [greater than or equal to]1year) and persistent abdominal pain ([greater than or equal to]14days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Cote d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.DISCUSSION:Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.TRIAL REGISTRATION:ClinicalTrials.gov; identifier: NCT02105714. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source BMC Infectious Diseases en_ZA
dc.source.uri http://www.biomedcentral.com/bmcinfectdis/ en_ZA
dc.subject.other Bacteria en_ZA
dc.subject.other Diagnosis-treatment algorithm en_ZA
dc.subject.other Helminths en_ZA
dc.subject.other Intestinal protozoa en_ZA
dc.subject.other Neglected tropical diseases en_ZA
dc.subject.other Persistent diarrhoea en_ZA
dc.subject.other Côte d’Ivoire en_ZA
dc.subject.other Indonesia en_ZA
dc.subject.other Mali en_ZA
dc.subject.other Nepal en_ZA
dc.title Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2015 Polman et al. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Public Health and Family Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Polman, K., Becker, S., Alirol, E., Bhatta, N., Bhattarai, N., Bottieau, E., ... (2015). Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study. <i>BMC Infectious Diseases</i>, http://hdl.handle.net/11427/15663 en_ZA
dc.identifier.chicagocitation Polman, Katja, Soren Becker, Emilie Alirol, Nisha Bhatta, Narayan Bhattarai, Emmanuel Bottieau, Martin Bratschi, et al "Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study." <i>BMC Infectious Diseases</i> (2015) http://hdl.handle.net/11427/15663 en_ZA
dc.identifier.vancouvercitation Polman K, Becker S, Alirol E, Bhatta N, Bhattarai N, Bottieau E, et al. Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study. BMC Infectious Diseases. 2015; http://hdl.handle.net/11427/15663. en_ZA
dc.identifier.ris TY - Journal Article AU - Polman, Katja AU - Becker, Soren AU - Alirol, Emilie AU - Bhatta, Nisha AU - Bhattarai, Narayan AU - Bottieau, Emmanuel AU - Bratschi, Martin AU - Burza, Sakib AU - Coulibaly, Jean AU - Doumbia, Mama AU - Horie, Ninon AU - Jacobs, Jan AU - Khanal, Basudha AU - Landoure, Aly AU - Mahendradhata, Yodi AU - Meheu AB - BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14days), the spectrum of pathogens that may give rise to persistent diarrhoea ([greater than or equal to]14days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.METHODS/DESIGN:This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea ([greater than or equal to]14days; in individuals aged [greater than or equal to]1year) and persistent abdominal pain ([greater than or equal to]14days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Cote d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.DISCUSSION:Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.TRIAL REGISTRATION:ClinicalTrials.gov; identifier: NCT02105714. DA - 2015 DB - OpenUCT DO - 10.1186/s12879-015-1074-x DP - University of Cape Town J1 - BMC Infectious Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study TI - Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study UR - http://hdl.handle.net/11427/15663 ER - en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record

This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License