Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study

 

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dc.contributor.author Yone, Eric Walter en_ZA
dc.contributor.author Balkissou, Adamou en_ZA
dc.contributor.author Kengne, Andre en_ZA
dc.contributor.author Kuaban, Christopher en_ZA
dc.date.accessioned 2015-12-07T08:52:15Z
dc.date.available 2015-12-07T08:52:15Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Yone, E. W. P., Balkissou, A. D., Kengne, A. P., & Kuaban, C. (2012). Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study. BMC pulmonary medicine, 12(1), 46. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15657
dc.identifier.uri http://dx.doi.org/10.1186/1471-2466-12-46
dc.description.abstract BACKGROUND: The impact of HIV infection on the evolution of acute community-acquired pneumonia (CAP) is still controversial. The aim of this study was to investigate possible differences in the clinical presentation and in-hospital outcomes of patients with CAP with and without HIV infection in a specialised service in Yaounde. METHODS: Medical files of 106 patients (51 men) aged 15years and above, admitted to the Pneumology service of the Yaounde Jamot Hospital between January 2008 and May 2012, were retrospectively studied. RESULTS: Sixty-two (58.5%) patients were HIV infected. The median age of all patients was 40years (interquartile range: 31.75-53) and there was no difference in the clinical and radiological profile of patients with and without HIV infection. The median leukocyte count (interquartile range) was 14,600/mm3 (10,900-20,600) and 10,450/mm3 (6,400-16,850) respectively in HIV negative and HIV positive patients (p=0.002). Median haemoglobin level (interquartile range) was 10.8g/dl (8.9-12) in HIV negative and 9.7g/dl (8-11.6) in HIV positive patients (p=0.025). In-hospital treatment failure on third day (39.5% vs. 25.5.1%, p=0.137) and mortality rates (9% vs. 14.5%, p=0.401) were similar between HIV negative and HIV positive patients. CONCLUSION: Clinical and radiological features as well as response to treatment and in hospital fatal outcomes are similar in adult patients hospitalised with acute community-acquired pneumonia in Yaounde. In contrast, HIV infected patients tend to be more anaemic and have lower white cell counts than HIV negative patients. Larger prospective studies are needed to consolidate these findings. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source BMC Pulmonary Medicine en_ZA
dc.source.uri http://www.biomedcentral.com/bmcpulmmed/ en_ZA
dc.subject.other Community-acquired pneumonia en_ZA
dc.subject.other HIV infection en_ZA
dc.subject.other Hospitalisation en_ZA
dc.subject.other Outcomes en_ZA
dc.subject.other Cameroon en_ZA
dc.title Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2012 Pefura Yone et al.; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Yone, E. W., Balkissou, A., Kengne, A., & Kuaban, C. (2012). Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study. <i>BMC Pulmonary Medicine</i>, http://hdl.handle.net/11427/15657 en_ZA
dc.identifier.chicagocitation Yone, Eric Walter, Adamou Balkissou, Andre Kengne, and Christopher Kuaban "Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study." <i>BMC Pulmonary Medicine</i> (2012) http://hdl.handle.net/11427/15657 en_ZA
dc.identifier.vancouvercitation Yone EW, Balkissou A, Kengne A, Kuaban C. Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study. BMC Pulmonary Medicine. 2012; http://hdl.handle.net/11427/15657. en_ZA
dc.identifier.ris TY - Journal Article AU - Yone, Eric Walter AU - Balkissou, Adamou AU - Kengne, Andre AU - Kuaban, Christopher AB - BACKGROUND: The impact of HIV infection on the evolution of acute community-acquired pneumonia (CAP) is still controversial. The aim of this study was to investigate possible differences in the clinical presentation and in-hospital outcomes of patients with CAP with and without HIV infection in a specialised service in Yaounde. METHODS: Medical files of 106 patients (51 men) aged 15years and above, admitted to the Pneumology service of the Yaounde Jamot Hospital between January 2008 and May 2012, were retrospectively studied. RESULTS: Sixty-two (58.5%) patients were HIV infected. The median age of all patients was 40years (interquartile range: 31.75-53) and there was no difference in the clinical and radiological profile of patients with and without HIV infection. The median leukocyte count (interquartile range) was 14,600/mm3 (10,900-20,600) and 10,450/mm3 (6,400-16,850) respectively in HIV negative and HIV positive patients (p=0.002). Median haemoglobin level (interquartile range) was 10.8g/dl (8.9-12) in HIV negative and 9.7g/dl (8-11.6) in HIV positive patients (p=0.025). In-hospital treatment failure on third day (39.5% vs. 25.5.1%, p=0.137) and mortality rates (9% vs. 14.5%, p=0.401) were similar between HIV negative and HIV positive patients. CONCLUSION: Clinical and radiological features as well as response to treatment and in hospital fatal outcomes are similar in adult patients hospitalised with acute community-acquired pneumonia in Yaounde. In contrast, HIV infected patients tend to be more anaemic and have lower white cell counts than HIV negative patients. Larger prospective studies are needed to consolidate these findings. DA - 2012 DB - OpenUCT DO - 10.1186/1471-2466-12-46 DP - University of Cape Town J1 - BMC Pulmonary Medicine LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study TI - Influence of HIV infection on the clinical presentation and outcome of adults with acute community-acquired pneumonia in Yaounde, Cameroon: a retrospective hospital-based study UR - http://hdl.handle.net/11427/15657 ER - en_ZA


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