Is air pollution a risk factor for rheumatoid arthritis?

 

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dc.contributor.author Essouma, Mickael en_ZA
dc.contributor.author Noubiap, Jean en_ZA
dc.date.accessioned 2015-12-07T08:52:10Z
dc.date.available 2015-12-07T08:52:10Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Essouma, M., & Noubiap, J. J. (2015). Is air pollution a risk factor for rheumatoid arthritis?. Journal of Inflammation, 12(1), 48. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15649
dc.identifier.uri http://dx.doi.org/10.1186/s12950-015-0092-1
dc.description.abstract Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case-control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution's effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source Journal of Inflammation en_ZA
dc.source.uri http://www.journal-inflammation.com/ en_ZA
dc.subject.other Rheumatoid arthritis en_ZA
dc.subject.other Pathogenesis en_ZA
dc.subject.other Environmental risk factors en_ZA
dc.subject.other Air pollution en_ZA
dc.title Is air pollution a risk factor for rheumatoid arthritis? en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2015 Essouma and Noubiap. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Essouma, M., & Noubiap, J. (2015). Is air pollution a risk factor for rheumatoid arthritis?. <i>Journal of Inflammation</i>, http://hdl.handle.net/11427/15649 en_ZA
dc.identifier.chicagocitation Essouma, Mickael, and Jean Noubiap "Is air pollution a risk factor for rheumatoid arthritis?." <i>Journal of Inflammation</i> (2015) http://hdl.handle.net/11427/15649 en_ZA
dc.identifier.vancouvercitation Essouma M, Noubiap J. Is air pollution a risk factor for rheumatoid arthritis?. Journal of Inflammation. 2015; http://hdl.handle.net/11427/15649. en_ZA
dc.identifier.ris TY - Journal Article AU - Essouma, Mickael AU - Noubiap, Jean AB - Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case-control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution's effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis. DA - 2015 DB - OpenUCT DO - 10.1186/s12950-015-0092-1 DP - University of Cape Town J1 - Journal of Inflammation LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Is air pollution a risk factor for rheumatoid arthritis? TI - Is air pollution a risk factor for rheumatoid arthritis? UR - http://hdl.handle.net/11427/15649 ER - en_ZA


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