Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

 

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dc.contributor.author Ghidelli-Disse, Sonja en_ZA
dc.contributor.author Lafuente-Monasterio, Maria en_ZA
dc.contributor.author Waterson, David en_ZA
dc.contributor.author Witty, Michael en_ZA
dc.contributor.author Younis, Yassir en_ZA
dc.contributor.author Paquet, Tanya en_ZA
dc.contributor.author Street, Leslie en_ZA
dc.contributor.author Chibale, Kelly en_ZA
dc.contributor.author Gamo-Benito, Francisco en_ZA
dc.contributor.author Bantscheff, Marcus en_ZA
dc.contributor.author Drewes, Gerard en_ZA
dc.date.accessioned 2015-11-27T09:35:20Z
dc.date.available 2015-11-27T09:35:20Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Ghidelli-Disse, S., Lafuente-Monasterio, M. J., Waterson, D., Witty, M., Younis, Y., Paquet, T., ... & Drewes, G. (2013). Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics. Malaria Journal, 13(Suppl 1), P38-P38. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15411
dc.identifier.uri http://dx.doi.org/10.1186/1475-2875-13-S1-P38
dc.description.abstract Most antimalarial drugs face decreased efficacy due to the emergence of resistant parasites. Therefore, the discovery of new antimalarial medicines is focused on new drugs that act by novel mechanisms and are active against different P. falciparum development stages. Screening of a focused compound library for antiparasitic activity, lead to identification of a novel class of compounds with activity against P. falciparum, 2-aminopyridines. The selected hits were validated and subjected to a lead optimization program resulting in the pre-clinical candidate MMV390048. Here we report an unbiased chemoproteomics strategy for the identification of targets of MMV390048. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0. en_ZA
dc.source Malaria Journal en_ZA
dc.source.uri http://www.malariajournal.com/ en_ZA
dc.subject.other antimalarial drugs en_ZA
dc.subject.other resistant parasites en_ZA
dc.title Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2014 Ghidelli-Disse et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Ghidelli-Disse, S., Lafuente-Monasterio, M., Waterson, D., Witty, M., Younis, Y., Paquet, T., ... Drewes, G. (2014). Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics. <i>Malaria Journal</i>, http://hdl.handle.net/11427/15411 en_ZA
dc.identifier.chicagocitation Ghidelli-Disse, Sonja, Maria Lafuente-Monasterio, David Waterson, Michael Witty, Yassir Younis, Tanya Paquet, Leslie Street, et al "Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics." <i>Malaria Journal</i> (2014) http://hdl.handle.net/11427/15411 en_ZA
dc.identifier.vancouvercitation Ghidelli-Disse S, Lafuente-Monasterio M, Waterson D, Witty M, Younis Y, Paquet T, et al. Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics. Malaria Journal. 2014; http://hdl.handle.net/11427/15411. en_ZA
dc.identifier.ris TY - Journal Article AU - Ghidelli-Disse, Sonja AU - Lafuente-Monasterio, Maria AU - Waterson, David AU - Witty, Michael AU - Younis, Yassir AU - Paquet, Tanya AU - Street, Leslie AU - Chibale, Kelly AU - Gamo-Benito, Francisco AU - Bantscheff, Marcus AU - Drewes, Gerard AB - Most antimalarial drugs face decreased efficacy due to the emergence of resistant parasites. Therefore, the discovery of new antimalarial medicines is focused on new drugs that act by novel mechanisms and are active against different P. falciparum development stages. Screening of a focused compound library for antiparasitic activity, lead to identification of a novel class of compounds with activity against P. falciparum, 2-aminopyridines. The selected hits were validated and subjected to a lead optimization program resulting in the pre-clinical candidate MMV390048. Here we report an unbiased chemoproteomics strategy for the identification of targets of MMV390048. DA - 2014 DB - OpenUCT DO - 10.1186/1475-2875-13-S1-P38 DP - University of Cape Town J1 - Malaria Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics TI - Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics UR - http://hdl.handle.net/11427/15411 ER - en_ZA


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