Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study

 

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dc.contributor.author Kaze, Francois en_ZA
dc.contributor.author Njukeng, Francis en_ZA
dc.contributor.author Kengne, Andre-Pascal en_ZA
dc.contributor.author Ashuntantang, Gloria en_ZA
dc.contributor.author Mbu, Robinson en_ZA
dc.contributor.author Halle, Marie en_ZA
dc.contributor.author Asonganyi, Tazoacha en_ZA
dc.date.accessioned 2015-11-27T09:33:41Z
dc.date.available 2015-11-27T09:33:41Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Kaze, F. F., Njukeng, F. A., Kengne, A. P., Ashuntantang, G., Mbu, R., Halle, M. P., & Asonganyi, T. (2014). Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study. BMC pregnancy and childbirth, 14(1), 134. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15400
dc.identifier.uri http://dx.doi.org/10.1186/1471-2393-14-134
dc.description.abstract BACKGROUND: Preeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia. METHODS: This was a prospective cohort study involving 54 women with severe preeclampsia and eclampsia, conducted between July 2010 and February 2012 at the central maternity unit of the Yaounde Central Hospital. Clinical and laboratory parameters were recorded from day-1 to 6months after delivery. Mixed-linear and logistic regression models were used to relate baseline and within follow-up levels of covariates, with changes in blood pressure levels, renal function and proteinuria, as well as persisting hypertension, renal failure and proteinuria. RESULTS: During follow-up, a significant improvement was observed in blood pressure, renal function and proteinuria (all p<0.002). Thirteen (24.1%) patients with renal failure at delivery recovered completely within six weeks. Twenty-six (48.1%), 17 (31.5%) and 1 (1.8%) patients had persisting proteinuria at 6weeks, 3months and 6months post-delivery, respectively. Corresponding figures for persisting hypertension were 23 (42.6%), 15 (27.8%) and 8 (14.8%). Advanced age, higher body mass index, low gestational age at delivery, low fetal birth weight, and proteinuria at delivery were the main risk factors for persisting hypertension at 3months, meanwhile low fetal birth weight, severe preeclampsia and proteinuria at delivery were correlated with persisting proteinuria at 3months. Advanced age and higher body mass index were the only determinants of the composite outcome of persisting hypertension or proteinuria at three and six months. CONCLUSION: Hypertension and proteinuria are very common beyond the postpartum period in Cameroonian women with severe preeclampsia and eclampsia. Long-term follow-up of these women will help preventing and controlling related complications. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source BMC Pregnancy and Childbirth en_ZA
dc.source.uri http://www.biomedcentral.com/bmcpregnancychildbirth/ en_ZA
dc.subject.other Preeclampsia en_ZA
dc.subject.other Eclampsia en_ZA
dc.subject.other Hypertension en_ZA
dc.subject.other Proteinuria en_ZA
dc.title Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2014 Kaze et al.; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Kaze, F., Njukeng, F., Kengne, A., Ashuntantang, G., Mbu, R., Halle, M., & Asonganyi, T. (2014). Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study. <i>BMC Pregnancy and Childbirth</i>, http://hdl.handle.net/11427/15400 en_ZA
dc.identifier.chicagocitation Kaze, Francois, Francis Njukeng, Andre-Pascal Kengne, Gloria Ashuntantang, Robinson Mbu, Marie Halle, and Tazoacha Asonganyi "Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study." <i>BMC Pregnancy and Childbirth</i> (2014) http://hdl.handle.net/11427/15400 en_ZA
dc.identifier.vancouvercitation Kaze F, Njukeng F, Kengne A, Ashuntantang G, Mbu R, Halle M, et al. Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study. BMC Pregnancy and Childbirth. 2014; http://hdl.handle.net/11427/15400. en_ZA
dc.identifier.ris TY - Journal Article AU - Kaze, Francois AU - Njukeng, Francis AU - Kengne, Andre-Pascal AU - Ashuntantang, Gloria AU - Mbu, Robinson AU - Halle, Marie AU - Asonganyi, Tazoacha AB - BACKGROUND: Preeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia. METHODS: This was a prospective cohort study involving 54 women with severe preeclampsia and eclampsia, conducted between July 2010 and February 2012 at the central maternity unit of the Yaounde Central Hospital. Clinical and laboratory parameters were recorded from day-1 to 6months after delivery. Mixed-linear and logistic regression models were used to relate baseline and within follow-up levels of covariates, with changes in blood pressure levels, renal function and proteinuria, as well as persisting hypertension, renal failure and proteinuria. RESULTS: During follow-up, a significant improvement was observed in blood pressure, renal function and proteinuria (all p<0.002). Thirteen (24.1%) patients with renal failure at delivery recovered completely within six weeks. Twenty-six (48.1%), 17 (31.5%) and 1 (1.8%) patients had persisting proteinuria at 6weeks, 3months and 6months post-delivery, respectively. Corresponding figures for persisting hypertension were 23 (42.6%), 15 (27.8%) and 8 (14.8%). Advanced age, higher body mass index, low gestational age at delivery, low fetal birth weight, and proteinuria at delivery were the main risk factors for persisting hypertension at 3months, meanwhile low fetal birth weight, severe preeclampsia and proteinuria at delivery were correlated with persisting proteinuria at 3months. Advanced age and higher body mass index were the only determinants of the composite outcome of persisting hypertension or proteinuria at three and six months. CONCLUSION: Hypertension and proteinuria are very common beyond the postpartum period in Cameroonian women with severe preeclampsia and eclampsia. Long-term follow-up of these women will help preventing and controlling related complications. DA - 2014 DB - OpenUCT DO - 10.1186/1471-2393-14-134 DP - University of Cape Town J1 - BMC Pregnancy and Childbirth LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study TI - Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study UR - http://hdl.handle.net/11427/15400 ER - en_ZA


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