Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans

 

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dc.contributor.author Sobngwi, Eugene en_ZA
dc.contributor.author Kengne, Andre-Pascal en_ZA
dc.contributor.author Echouffo-Tcheugui, Justin en_ZA
dc.contributor.author Choukem, Simeon en_ZA
dc.contributor.author Sobngwi-Tambekou, Joelle en_ZA
dc.contributor.author Balti, Eric en_ZA
dc.contributor.author Pearce, Mark en_ZA
dc.contributor.author Siaha, Valentin en_ZA
dc.contributor.author Mamdjokam, Aissa en_ZA
dc.contributor.author Effoe, Valery en_ZA
dc.contributor.author Lontchi-Yimagou, Eric en_ZA
dc.contributor.author Donfack, Oliver en_ZA
dc.contributor.author Atogho-Tiedeu, Barbara en_ZA
dc.date.accessioned 2015-11-27T09:33:37Z
dc.date.available 2015-11-27T09:33:37Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Sobngwi, E., Kengne, A. P., Echouffo-Tcheugui, J. B., Choukem, S., Sobngwi-Tambekou, J., Balti, E. V., ... & Mbanya, J. C. (2014). Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans. BMC endocrine disorders, 14(1), 65. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15396
dc.identifier.uri http://dx.doi.org/10.1186/1472-6823-14-65
dc.description.abstract BACKGROUND: We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes. METHODS: We measured fasting glucose and insulin, and glucose uptake during 80/mU/m2/min euglycemic clamp in 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. We derived insulin sensitivity indices including HOMA-IR, quantitative insulin sensitivity check index (QUICKI), fasting insulin resistance index (FIRI) and glucose-to-insulin ratio (GIR). Indices and clinical predictors were compared to clamp using correlation tests, robust linear regressions and agreement of classification by sex-specific thirds. RESULTS: The mean insulin sensitivity was M =10.5+/-3.2mg/kg/min. Classification across thirds of insulin sensitivity by clamp matched with non-laboratory surrogates in 30-48% of participants, and with fasting indices in 27-51%, with kappa statistics ranging from 0.10 to 0.26. Fasting indices correlated significantly with clamp (/r/=0.23-0.30), with GIR performing less well than fasting insulin and HOMA-IR (both p <0.02). BMI, WC and WHtR were equal or superior to fasting indices (/r/=0.38-0.43). Combinations of fasting indices and clinical predictors explained 25-27% of variation in clamp values. CONCLUSION: Fasting insulin sensitivity indices are modest predictors of insulin sensitivity measured by euglycemic clamp, and do not perform better than clinical surrogates in this population. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0. en_ZA
dc.source BMC Endocrine Disorders en_ZA
dc.source.uri http://www.biomedcentral.com/bmcendocrdisord/ en_ZA
dc.subject.other fasting insulin sensitivity indices en_ZA
dc.subject.other sub-Saharan Africans en_ZA
dc.subject.other diabetes en_ZA
dc.title Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2014 Sobngwi et al.; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Sobngwi, E., Kengne, A., Echouffo-Tcheugui, J., Choukem, S., Sobngwi-Tambekou, J., Balti, E., ... Atogho-Tiedeu, B. (2014). Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans. <i>BMC Endocrine Disorders</i>, http://hdl.handle.net/11427/15396 en_ZA
dc.identifier.chicagocitation Sobngwi, Eugene, Andre-Pascal Kengne, Justin Echouffo-Tcheugui, Simeon Choukem, Joelle Sobngwi-Tambekou, Eric Balti, Mark Pearce, et al "Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans." <i>BMC Endocrine Disorders</i> (2014) http://hdl.handle.net/11427/15396 en_ZA
dc.identifier.vancouvercitation Sobngwi E, Kengne A, Echouffo-Tcheugui J, Choukem S, Sobngwi-Tambekou J, Balti E, et al. Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans. BMC Endocrine Disorders. 2014; http://hdl.handle.net/11427/15396. en_ZA
dc.identifier.ris TY - Journal Article AU - Sobngwi, Eugene AU - Kengne, Andre-Pascal AU - Echouffo-Tcheugui, Justin AU - Choukem, Simeon AU - Sobngwi-Tambekou, Joelle AU - Balti, Eric AU - Pearce, Mark AU - Siaha, Valentin AU - Mamdjokam, Aissa AU - Effoe, Valery AU - Lontchi-Yimagou, Eric AU - Donfack, Oliver AU - Atogho-Tiedeu, Barbara AB - BACKGROUND: We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes. METHODS: We measured fasting glucose and insulin, and glucose uptake during 80/mU/m2/min euglycemic clamp in 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. We derived insulin sensitivity indices including HOMA-IR, quantitative insulin sensitivity check index (QUICKI), fasting insulin resistance index (FIRI) and glucose-to-insulin ratio (GIR). Indices and clinical predictors were compared to clamp using correlation tests, robust linear regressions and agreement of classification by sex-specific thirds. RESULTS: The mean insulin sensitivity was M =10.5+/-3.2mg/kg/min. Classification across thirds of insulin sensitivity by clamp matched with non-laboratory surrogates in 30-48% of participants, and with fasting indices in 27-51%, with kappa statistics ranging from 0.10 to 0.26. Fasting indices correlated significantly with clamp (/r/=0.23-0.30), with GIR performing less well than fasting insulin and HOMA-IR (both p <0.02). BMI, WC and WHtR were equal or superior to fasting indices (/r/=0.38-0.43). Combinations of fasting indices and clinical predictors explained 25-27% of variation in clamp values. CONCLUSION: Fasting insulin sensitivity indices are modest predictors of insulin sensitivity measured by euglycemic clamp, and do not perform better than clinical surrogates in this population. DA - 2014 DB - OpenUCT DO - 10.1186/1472-6823-14-65 DP - University of Cape Town J1 - BMC Endocrine Disorders LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans TI - Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans UR - http://hdl.handle.net/11427/15396 ER - en_ZA


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