HHV-8 seroprevalence: a global view

 

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dc.contributor.author Rohner, Eliane en_ZA
dc.contributor.author Wyss, Natascha en_ZA
dc.contributor.author Trelle, Sven en_ZA
dc.contributor.author Mbulaiteye, Sam en_ZA
dc.contributor.author Egger, Matthias en_ZA
dc.contributor.author Novak, Urban en_ZA
dc.contributor.author Zwahlen, Marcel en_ZA
dc.contributor.author Bohlius, Julia en_ZA
dc.date.accessioned 2015-11-27T09:30:17Z
dc.date.available 2015-11-27T09:30:17Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Rohner, E., Wyss, N., Trelle, S., Mbulaiteye, S. M., Egger, M., Novak, U., ... & Bohlius, J. (2014). HHV-8 seroprevalence: a global view. Systematic Reviews, 3(1), 11. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15381
dc.identifier.uri http://dx.doi.org/10.1186/2046-4053-3-11
dc.description.abstract BACKGROUND: Human herpes virus 8 (HHV-8) is the underlying infectious cause of Kaposi sarcoma (KS) and other proliferative diseases; that is, primary effusion lymphoma and multicentric Castleman disease. In regions with high HHV-8 seroprevalence in the general population, KS accounts for a major burden of disease. Outside these endemic regions, HHV-8 prevalence is high in men who have sex with men (MSM) and in migrants from endemic regions. We aim to conduct a systematic literature review and meta-analysis in order 1) to define the global distribution of HHV-8 seroprevalence (primary objective) and 2) to identify risk factors for HHV-8 infection, with a focus on HIV status (secondary objective).METHODS/DESIGN:We will include observational studies reporting data on seroprevalence of HHV-8 in children and/or adults from any region in the world. Case reports and case series as well as any studies with fewer than 50 participants will be excluded. We will search MEDLINE, EMBASE, and relevant conference proceedings without language restriction. Two reviewers will independently screen the identified studies and extract data on study characteristics and quality, study population, risk factors, and reported outcomes, using a standardized form. For the primary objective we will pool the data using a fully bayesian approach for meta-analysis, with random effects at the study level. For the secondary objective (association of HIV and HHV-8) we aim to pool odds ratios for the association of HIV and HHV-8 using a fully bayesian approach for meta-analysis, with random effects at the study level. Sub-group analyses and meta-regression analyses will be used to explore sources of heterogeneity, including factors such as geographical region, calendar years of recruitment, age, gender, ethnicity, socioeconomic status, different risk groups for sexually and parenterally transmitted infections (MSM, sex workers, hemophiliacs, intravenous drug users), comorbidities such as organ transplantation and malaria, test(s) used to measure HHV-8 infection, study design, and study quality.DISCUSSION:Using the proposed systematic review and meta-analysis, we aim to better define the global seroprevalence of HHV-8 and its associated risk factors. This will improve the current understanding of HHV-8 epidemiology, and could suggest measures to prevent HHV-8 infection and to reduce its associated cancer burden. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Systematic Reviews en_ZA
dc.source.uri http://www.systematicreviewsjournal.com/ en_ZA
dc.subject.other HHV-8 en_ZA
dc.subject.other Kaposi sarcoma en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Seroprevalence en_ZA
dc.subject.other Meta-analysis en_ZA
dc.title HHV-8 seroprevalence: a global view en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2014 Rohner et al.; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License