The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda

 

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dc.contributor.author Akena, Dickens en_ZA
dc.contributor.author Musisi, Seggane en_ZA
dc.contributor.author Joska, John en_ZA
dc.contributor.author Stein, Dan J en_ZA
dc.date.accessioned 2015-11-23T12:37:50Z
dc.date.available 2015-11-23T12:37:50Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Akena, D., Musisi, S., Joska, J., & Stein, D. J. (2011). The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda. PloS one, 7(11), e48671. doi:10.1371/journal.pone.0048671 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15358
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0048671
dc.description.abstract BACKGROUND: Major depressive disorder in people living with HIV/AIDS (PLWHA) is common and may be associated with a number of factors, including AIDS-related stigma, decreased CD4 levels, increased opportunistic infections and sociodemographic variables. The extent to which AIDS-related stigma is associated with major depressive disorder among PLWHA has not been well studied in sub-Saharan Africa. The objective of this study was to examine the associations between major depressive disorder, AIDS-related stigma, immune status, and sociodemographic variables with the aim of making recommendations that can guide clinicians. METHODS: We assessed 368 PLWHA for major depressive disorder, as well as for potentially associated factors, including AIDS-related stigma, CD4 levels, presence of opportunistic infections, and sociodemographic variables. RESULTS: The prevalence of major depressive disorder was 17.4%, while 7.9% of the participants had AIDS related stigma. At multivariable analysis, major depressive disorder was significantly associated with AIDS-related stigma [OR = 1.65, CI (1.20-2.26)], a CD4 count of ≥200 [OR 0.52 CI (0.27-0.99)], and being of younger age [0.95, CI (0.92-0.98). CONCLUSIONS: Due to the high burden of major depressive disorder, and its association with AIDS related stigma, routine screening of PLWHA for both conditions is recommended. However, more research is required to understand this association. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Depression en_ZA
dc.subject.other AIDS en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Opportunistic infections en_ZA
dc.subject.other Bivariate analysis en_ZA
dc.subject.other Africa en_ZA
dc.subject.other Antiretroviral therapy en_ZA
dc.subject.other Quality of life en_ZA
dc.title The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2012 Akena et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Psychiatry and Mental Health en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.