Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection

 

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dc.contributor.author Radwanska, Magdalena en_ZA
dc.contributor.author Cutler, Antony J en_ZA
dc.contributor.author Hoving, J Claire en_ZA
dc.contributor.author Magez, Stefan en_ZA
dc.contributor.author Holscher, Christoph en_ZA
dc.contributor.author Bohms, Andreas en_ZA
dc.contributor.author Arendse, Berenice en_ZA
dc.contributor.author Kirsch, Richard en_ZA
dc.contributor.author Hunig, Thomas en_ZA
dc.contributor.author Alexander, James en_ZA
dc.date.accessioned 2015-11-23T12:35:24Z
dc.date.available 2015-11-23T12:35:24Z
dc.date.issued 2007 en_ZA
dc.identifier.citation Radwanska, M., Cutler, A. J., Hoving, J. C., Magez, S., Holscher, C., Bohms, A., ... & Brombacher, F. (2007). Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. PLoS Pathog, 3(5), e68. doi:10.1371/journal.ppat.0030068 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15327
dc.identifier.uri http://dx.doi.org/10.1371/journal.ppat.0030068
dc.description.abstract Author Summary Leishmaniasis is a disease induced by a protozoan parasite and transmitted by the sandfly. Several forms of infection are identified, and the different diseases have wide-ranging symptoms from localized cutaneous sores to visceral disease affecting many internal organs. Animal models of human cutaneous leishmaniasis have been established in which disease is induced by infecting mice subcutaneously with Leishmania major. Different strains of inbred mice have been found to be susceptible or resistant to L. major infection. "Healer" C57BL/6 mice control infection with transient lesion development. The protective response to infection in this strain is dominated by type 1 cytokines inducing parasite killing by nitric oxide. Conversely, "nonhealer" BALB/c mice are unable to control infection and develop nonhealing lesions associated with a dominant type 2 immune response driven by cytokines IL-4 and IL-13. However, mice deficient in IL-4/IL-13 signaling are not protected against development of cutaneous leishmaniasis. Here we describe a BALB/c mouse where the ability to polarize to a dominant type 2 response is removed by cell-specific deletion of the receptor for IL-4/IL-13 on CD4 + T cells. These mice are resistant to L. major infection similar to C57BL/6 mice, which highlights the role of T helper 2 cells in driving susceptibility and the protective role of IL-4/IL-13 signaling in non-CD4 + T cells in BALB/c mice. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plospathogens en_ZA
dc.subject.other T cells en_ZA
dc.subject.other Leishmania major en_ZA
dc.subject.other Macrophages en_ZA
dc.subject.other Mouse models en_ZA
dc.subject.other Parasitic diseases en_ZA
dc.subject.other Immune response en_ZA
dc.subject.other Infectious disease control en_ZA
dc.subject.other Cytokines en_ZA
dc.title Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2007 Radwanska et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Immunology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Radwanska, M., Cutler, A. J., Hoving, J. C., Magez, S., Holscher, C., Bohms, A., ... Alexander, J. (2007). Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. <i>PLoS One</i>, http://hdl.handle.net/11427/15327 en_ZA
dc.identifier.chicagocitation Radwanska, Magdalena, Antony J Cutler, J Claire Hoving, Stefan Magez, Christoph Holscher, Andreas Bohms, Berenice Arendse, Richard Kirsch, Thomas Hunig, and James Alexander "Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection." <i>PLoS One</i> (2007) http://hdl.handle.net/11427/15327 en_ZA
dc.identifier.vancouvercitation Radwanska M, Cutler AJ, Hoving JC, Magez S, Holscher C, Bohms A, et al. Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. PLoS One. 2007; http://hdl.handle.net/11427/15327. en_ZA
dc.identifier.ris TY - Journal Article AU - Radwanska, Magdalena AU - Cutler, Antony J AU - Hoving, J Claire AU - Magez, Stefan AU - Holscher, Christoph AU - Bohms, Andreas AU - Arendse, Berenice AU - Kirsch, Richard AU - Hunig, Thomas AU - Alexander, James AB - Author Summary Leishmaniasis is a disease induced by a protozoan parasite and transmitted by the sandfly. Several forms of infection are identified, and the different diseases have wide-ranging symptoms from localized cutaneous sores to visceral disease affecting many internal organs. Animal models of human cutaneous leishmaniasis have been established in which disease is induced by infecting mice subcutaneously with Leishmania major. Different strains of inbred mice have been found to be susceptible or resistant to L. major infection. "Healer" C57BL/6 mice control infection with transient lesion development. The protective response to infection in this strain is dominated by type 1 cytokines inducing parasite killing by nitric oxide. Conversely, "nonhealer" BALB/c mice are unable to control infection and develop nonhealing lesions associated with a dominant type 2 immune response driven by cytokines IL-4 and IL-13. However, mice deficient in IL-4/IL-13 signaling are not protected against development of cutaneous leishmaniasis. Here we describe a BALB/c mouse where the ability to polarize to a dominant type 2 response is removed by cell-specific deletion of the receptor for IL-4/IL-13 on CD4 + T cells. These mice are resistant to L. major infection similar to C57BL/6 mice, which highlights the role of T helper 2 cells in driving susceptibility and the protective role of IL-4/IL-13 signaling in non-CD4 + T cells in BALB/c mice. DA - 2007 DB - OpenUCT DO - 10.1371/journal.ppat.0030068 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection TI - Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection UR - http://hdl.handle.net/11427/15327 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.