Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses

 

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dc.contributor.author Gervassi, Ana en_ZA
dc.contributor.author Lejarcegui, Nicholas en_ZA
dc.contributor.author Dross, Sandra en_ZA
dc.contributor.author Jacobson, Amanda en_ZA
dc.contributor.author Itaya, Grace en_ZA
dc.contributor.author Kidzeru, Elvis en_ZA
dc.contributor.author Gantt, Soren en_ZA
dc.contributor.author Jaspan, Heather en_ZA
dc.contributor.author Horton, Helen en_ZA
dc.date.accessioned 2015-11-23T12:35:20Z
dc.date.available 2015-11-23T12:35:20Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Gervassi, A., Lejarcegui, N., Dross, S., Jacobson, A., Itaya, G., Kidzeru, E., ... & Horton, H. (2014). Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. PloS one, 9(9), e107816. doi:10.1371/journal.pone.0107816 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15323
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0107816
dc.description.abstract Over 4 million infants die each year from infections, many of which are vaccine-preventable. Young infants respond relatively poorly to many infections and vaccines, but the basis of reduced immunity in infants is ill defined. We sought to investigate whether myeloid-derived suppressor cells (MDSC) represent one potential impediment to protective immunity in early life, which may help inform strategies for effective vaccination prior to pathogen exposure. We enrolled healthy neonates and children in the first 2 years of life along with healthy adult controls to examine the frequency and function of MDSC, a cell population able to potently suppress T cell responses. We found that MDSC, which are rarely seen in healthy adults, are present in high numbers in neonates and their frequency rapidly decreases during the first months of life. We determined that these neonatal MDSC are of granulocytic origin (G-MDSC), and suppress both CD4+ and CD8+ T cell proliferative responses in a contact-dependent manner and gamma interferon production. Understanding the role G-MDSC play in infant immunity could improve vaccine responsiveness in newborns and reduce mortality due to early-life infections. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other T cells en_ZA
dc.subject.other Adults en_ZA
dc.subject.other Infants en_ZA
dc.subject.other Neutrophils en_ZA
dc.subject.other Blood en_ZA
dc.subject.other Immune response en_ZA
dc.subject.other Neonates en_ZA
dc.subject.other Vaccines en_ZA
dc.title Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2014 Gervassi et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Immunology en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.