Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients

 

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dc.contributor.author Ross, Ian Louis en_ZA
dc.contributor.author Bergthorsdottir, Ragnhildur en_ZA
dc.contributor.author Levitt, Naomi en_ZA
dc.contributor.author Dave, Joel Alex en_ZA
dc.contributor.author Schatz, Desmond en_ZA
dc.contributor.author Marais, David en_ZA
dc.contributor.author Johannsson, Gudmundur en_ZA
dc.date.accessioned 2015-11-23T12:29:22Z
dc.date.available 2015-11-23T12:29:22Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Ross, I. L., Bergthorsdottir, R., Levitt, N., Dave, J. A., Schatz, D., Marais, D., & Johannsson, G. (2014). Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients. PloS one, 9(3). doi:10.1371/journal.pone.0090768 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15298
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0090768
dc.description.abstract BACKGROUND: Patients with Addison's disease (AD) in Scandinavia have an increased risk for premature death due to cardiovascular disease (CVD). Serum lipids are important risk factors for CVD and vascular mortality. Replacement doses of hydrocortisone have historically been higher in Sweden than South Africa. The primary aim was to study the lipid profiles in a large group of patients with AD with the hypothesis that the lipid profile in patients in Sweden would be worse than in South Africa. METHODS: In a cross-sectional study, 110 patients with AD (55 from South Africa, 55 from Sweden) matched for age, gender, ethnicity and BMI were studied. Anthropometric measures, blood pressure, lipids, highly sensitive C-reactive protein (hs-CRP) and adiponectin were studied. RESULTS: All patients were Caucasian and the majority were women N = 36 (65.5%). Mean (standard deviation; SD) ages of the Swedish and South African patients were 52.9 (13.0) and 52.6 (14.4) years and BMI 25.3 (3.2) and 25.8 (4.1) kg/m 2 , respectively. The mean total daily hydrocortisone dose was greater in the Swedish patients than the South African patients, [33.0 (8.1) versus 24.3 (8.0) mg; p<0.0001]. South African patients had higher median (interquartilerange; IQR) triglycerides (TG) [1.59 (1.1-2.46) versus 0.96 (0.74-1.6) mmol/l; p<0.001], total cholesterol (TC) [6.02(1.50) versus 5.13 (0.87) mmol/l; p<0.001], LDL-C [4.43 (1.44) versus 2.75 (0.80) mmol/l; p<0.001] and median hs-CRP [2.15 (0.93-5.45) versus 0.99 (0.57-2.10) mg/L; p<0.003] and lower HDL-C [0.80 (0.40) versus 1.86 (0.46) mmol/l; p<0.001] than the Swedish patients. Approximately 20% of the patients in both cohorts had hypertension and diabetes mellitus. CONCLUSIONS: South African patients with AD have worse lipid profiles and higher hs-CRP compared to their matched Swedish patients, despite lower doses of hydrocortisone. It is uncertain at this time whether these are due to genetic or environmental factors. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Africans en_ZA
dc.subject.other Hydrocortisone en_ZA
dc.subject.other Cardiovascular diseases en_ZA
dc.subject.other Swedes en_ZA
dc.subject.other Lipids en_ZA
dc.subject.other Diabetes mellitus en_ZA
dc.subject.other Lipid profiles en_ZA
dc.subject.other Adiponectin en_ZA
dc.title Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2014 Ross et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Endocrinology and Diabetology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Ross, I. L., Bergthorsdottir, R., Levitt, N., Dave, J. A., Schatz, D., Marais, D., & Johannsson, G. (2014). Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients. <i>PLoS One</i>, http://hdl.handle.net/11427/15298 en_ZA
dc.identifier.chicagocitation Ross, Ian Louis, Ragnhildur Bergthorsdottir, Naomi Levitt, Joel Alex Dave, Desmond Schatz, David Marais, and Gudmundur Johannsson "Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients." <i>PLoS One</i> (2014) http://hdl.handle.net/11427/15298 en_ZA
dc.identifier.vancouvercitation Ross IL, Bergthorsdottir R, Levitt N, Dave JA, Schatz D, Marais D, et al. Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients. PLoS One. 2014; http://hdl.handle.net/11427/15298. en_ZA
dc.identifier.ris TY - Journal Article AU - Ross, Ian Louis AU - Bergthorsdottir, Ragnhildur AU - Levitt, Naomi AU - Dave, Joel Alex AU - Schatz, Desmond AU - Marais, David AU - Johannsson, Gudmundur AB - BACKGROUND: Patients with Addison's disease (AD) in Scandinavia have an increased risk for premature death due to cardiovascular disease (CVD). Serum lipids are important risk factors for CVD and vascular mortality. Replacement doses of hydrocortisone have historically been higher in Sweden than South Africa. The primary aim was to study the lipid profiles in a large group of patients with AD with the hypothesis that the lipid profile in patients in Sweden would be worse than in South Africa. METHODS: In a cross-sectional study, 110 patients with AD (55 from South Africa, 55 from Sweden) matched for age, gender, ethnicity and BMI were studied. Anthropometric measures, blood pressure, lipids, highly sensitive C-reactive protein (hs-CRP) and adiponectin were studied. RESULTS: All patients were Caucasian and the majority were women N = 36 (65.5%). Mean (standard deviation; SD) ages of the Swedish and South African patients were 52.9 (13.0) and 52.6 (14.4) years and BMI 25.3 (3.2) and 25.8 (4.1) kg/m 2 , respectively. The mean total daily hydrocortisone dose was greater in the Swedish patients than the South African patients, [33.0 (8.1) versus 24.3 (8.0) mg; p<0.0001]. South African patients had higher median (interquartilerange; IQR) triglycerides (TG) [1.59 (1.1-2.46) versus 0.96 (0.74-1.6) mmol/l; p<0.001], total cholesterol (TC) [6.02(1.50) versus 5.13 (0.87) mmol/l; p<0.001], LDL-C [4.43 (1.44) versus 2.75 (0.80) mmol/l; p<0.001] and median hs-CRP [2.15 (0.93-5.45) versus 0.99 (0.57-2.10) mg/L; p<0.003] and lower HDL-C [0.80 (0.40) versus 1.86 (0.46) mmol/l; p<0.001] than the Swedish patients. Approximately 20% of the patients in both cohorts had hypertension and diabetes mellitus. CONCLUSIONS: South African patients with AD have worse lipid profiles and higher hs-CRP compared to their matched Swedish patients, despite lower doses of hydrocortisone. It is uncertain at this time whether these are due to genetic or environmental factors. DA - 2014 DB - OpenUCT DO - 10.1371/journal.pone.0090768 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients TI - Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients UR - http://hdl.handle.net/11427/15298 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.