Is obesity a risk factor for vaccine non-responsiveness?

 

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dc.contributor.author Young, Katherine M en_ZA
dc.contributor.author Gray, Clive M en_ZA
dc.contributor.author Bekker, Linda-Gail en_ZA
dc.date.accessioned 2015-11-23T12:25:39Z
dc.date.available 2015-11-23T12:25:39Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Young, K. M., Gray, C. M., & Bekker, L. G. (2012). Is obesity a risk factor for vaccine non-responsiveness?. PloS one, 8(12), e82779. doi:10.1371/journal.pone.0082779 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15275
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0082779
dc.description.abstract Understanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious vaccines. We undertook a study to explore clinical predictors of vaccine efficacy following recombinant hepatitis B (rHBV) vaccination in a cohort of HIV-uninfected, hepatitis B virus naïve women living in a peri-urban setting in Cape Town. Our aim was to define host biological risk factors associated with lack of vaccine uptake. We found a significant association (p=0.009) between body mass index (BMI) and lack of vaccine-specific IgG titre (<10mIU/mL). Obese individuals (BMI ≥ 30kg/m 2 ) were significantly more likely to be non-responders following 2 rHBV vaccine doses (Adjusted Odds Ratio of 8.75; p=0.043). There was no observed association between vaccine responses and age, method of contraception or time from vaccination to antibody measurement. These data suggest that obesity-associated factors interfere with vaccine immunogenicity and possible efficacy. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Vaccines en_ZA
dc.subject.other HIV vaccines en_ZA
dc.subject.other Body mass index en_ZA
dc.subject.other Obesity en_ZA
dc.subject.other Vaccination and immunization en_ZA
dc.subject.other Vaccine development en_ZA
dc.subject.other HIV-1 en_ZA
dc.subject.other HIV en_ZA
dc.title Is obesity a risk factor for vaccine non-responsiveness? en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2013 Young et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Desmond Tutu HIV Centre en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Young, K. M., Gray, C. M., & Bekker, L. (2013). Is obesity a risk factor for vaccine non-responsiveness?. <i>PLoS One</i>, http://hdl.handle.net/11427/15275 en_ZA
dc.identifier.chicagocitation Young, Katherine M, Clive M Gray, and Linda-Gail Bekker "Is obesity a risk factor for vaccine non-responsiveness?." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/15275 en_ZA
dc.identifier.vancouvercitation Young KM, Gray CM, Bekker L. Is obesity a risk factor for vaccine non-responsiveness?. PLoS One. 2013; http://hdl.handle.net/11427/15275. en_ZA
dc.identifier.ris TY - Journal Article AU - Young, Katherine M AU - Gray, Clive M AU - Bekker, Linda-Gail AB - Understanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious vaccines. We undertook a study to explore clinical predictors of vaccine efficacy following recombinant hepatitis B (rHBV) vaccination in a cohort of HIV-uninfected, hepatitis B virus naïve women living in a peri-urban setting in Cape Town. Our aim was to define host biological risk factors associated with lack of vaccine uptake. We found a significant association (p=0.009) between body mass index (BMI) and lack of vaccine-specific IgG titre (<10mIU/mL). Obese individuals (BMI ≥ 30kg/m 2 ) were significantly more likely to be non-responders following 2 rHBV vaccine doses (Adjusted Odds Ratio of 8.75; p=0.043). There was no observed association between vaccine responses and age, method of contraception or time from vaccination to antibody measurement. These data suggest that obesity-associated factors interfere with vaccine immunogenicity and possible efficacy. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0082779 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Is obesity a risk factor for vaccine non-responsiveness? TI - Is obesity a risk factor for vaccine non-responsiveness? UR - http://hdl.handle.net/11427/15275 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.