Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study

 

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dc.contributor.author Sinxadi, Phumla en_ZA
dc.contributor.author McIlleron, Helen en_ZA
dc.contributor.author Dave, Joel en_ZA
dc.contributor.author Smith, Peter en_ZA
dc.contributor.author Levitt, Naomi en_ZA
dc.contributor.author Maartens, Gary en_ZA
dc.date.accessioned 2015-11-23T12:08:34Z
dc.date.available 2015-11-23T12:08:34Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Sinxadi, P. Z., McIlleron, H. M., Dave, J. A., Smith, P. J., Levitt, N. S., & Maartens, G. (2012). Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study. AIDS research and therapy, 9(1), 1-6. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15249
dc.identifier.uri http://dx.doi.org/10.1186/1742-6405-9-32
dc.description.abstract BACKGROUND: Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor in resource-limited settings, often causes dyslipidaemia. There are contradictory data regarding the association between lopinavir concentrations and changes in lipids.AIM:To investigate associations between plasma lopinavir concentrations and lipid and glucose concentrations in HIV-infected South African adults. METHODS: Participants stable on lopinavir-based antiretroviral therapy were enrolled into a cross-sectional study. After an overnight fast, total cholesterol, triglycerides, and lopinavir concentrations were measured and an oral glucose tolerance test was performed. Regression analyses were used to determine associations between plasma lopinavir concentrations and fasting and 2 hour plasma glucose, fasting cholesterol, and triglycerides concentrations. RESULTS: There were 84 participants (72 women) with a median age of 36 years. The median blood pressure, body mass index and waist: hip ratio were 108/72 mmHg, 26 kg/m2 and 0.89 respectively. The median CD4 count was 478 cells/mm3. Median duration on lopinavir was 18.5 months. The median (interquartile range) lopinavir concentration was 8.0 (5.2 to 12.8) mug/mL. Regression analyses showed no significant association between lopinavir pre-dose concentrations and fasting cholesterol (beta-coefficient 0.04 (95% CI 0.07 to 0.00)), triglycerides (beta-coefficient 0.01 (95% CI 0.04 to 0.02)), fasting glucose (beta-coefficient 0.01 (95% CI 0.04 to 0.02)), or 2-hour glucose concentrations (beta-coefficient 0.02 (95% CI 0.09 to 0.06)). Lopinavir concentrations above the median were not associated with presence of dyslipidaemia or dysglycaemia. CONCLUSIONS: There was no association between lopinavir plasma concentrations and plasma lipid and glucose concentrations. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source AIDS Research and Therapy en_ZA
dc.source.uri http://aidsrestherapy.biomedcentral.com/ en_ZA
dc.subject.other Lopinavir en_ZA
dc.subject.other Hypercholesterolaemia en_ZA
dc.subject.other Hypertriglyceridaemia en_ZA
dc.subject.other Impaired glucose metabolism en_ZA
dc.subject.other Antiretroviral therapy en_ZA
dc.subject.other Pharmacokinetics en_ZA
dc.title Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study en_ZA
dc.type Journal Article en_ZA
dc.rights.holder Sinxadi et al.; licensee BioMed Central Ltd. 2012 en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License