Understanding interventions for improving routine immunization coverage in children in low- and middle-income countries: a systematic review protocol

 

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dc.contributor.author Machingaidze, Shingai en_ZA
dc.contributor.author Rehfuess, Eva en_ZA
dc.contributor.author von Kries, Rudiger en_ZA
dc.contributor.author Hussey, Gregory en_ZA
dc.contributor.author Wiysonge, Charles en_ZA
dc.date.accessioned 2015-11-23T11:44:12Z
dc.date.available 2015-11-23T11:44:12Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Machingaidze, S., Rehfuess, E., von Kries, R., Hussey, G. D., & Wiysonge, C. S. (2013). Understanding interventions for improving routine immunization coverage in children in low-and middle-income countries: a systematic review protocol. Systematic reviews, 2(1), 106. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15242
dc.identifier.uri http://dx.doi.org/10.1186/2046-4053-2-106
dc.description.abstract BACKGROUND: Virtually all low- and middle-income countries are dependent on the World Health Organization's Expanded Program on Immunization for delivery of vaccines to children. The Expanded Program on Immunization delivers routine immunization services from health facilities free of charge. Understanding interventions for improving immunization coverage remains key in achieving universal childhood immunization. METHODS: We will conduct a systematic review that aims to assess the effectiveness of the full range of potential interventions to improve routine immunization coverage in children in low- and middle-income countries. We will include intervention studies, as well as observational studies. We will search the Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, electronic databases for eligible studies published by 31 August 2013. At least two authors will independently screen search outputs, select studies, extract data and assess the risk of bias (using separate criteria for interventions and observational studies); resolving any disagreements by discussion and consensus. The use of logic models and the Cochrane Complexity Matrix will be explored in order to better understand and contextualize studies. We will express the result of each study as a risk ratio with its corresponding 95% confidence intervals for dichotomous data, or mean difference with its standard deviation for continuous data. We will conduct meta-analysis for the same type of participants, interventions, study designs, and outcome measures where homogeneity of data allows. Use of harvest plots may be explored as an alternative. Heterogeneity will be assessed using the chi2 test of heterogeneity, and quantified using the I2 statistic. This protocol has not been registered with PROSPERO.DISCUSSION:This review will allow us to document evidence across a broad range of intervention types for improving routine immunization coverage in children and also distinguish between those that are well supported by evidence (to direct policy recommendations) and those that are not well supported (to direct research agenda). en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Systematic Reviews en_ZA
dc.source.uri http://www.systematicreviewsjournal.com/ en_ZA
dc.subject.other Expanded Program on Immunization (EPI) en_ZA
dc.subject.other Routine immunization en_ZA
dc.subject.other Routine vaccination en_ZA
dc.subject.other Children en_ZA
dc.subject.other Low- and middle-income countries en_ZA
dc.title Understanding interventions for improving routine immunization coverage in children in low- and middle-income countries: a systematic review protocol en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2013 Machingaidze et al.; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License