Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility?

 

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dc.contributor.author Carstens, Madelaine en_ZA
dc.contributor.author Goedecke, Julia en_ZA
dc.contributor.author Dugas, Lara en_ZA
dc.contributor.author Evans, Juliet en_ZA
dc.contributor.author Kroff, Jacolene en_ZA
dc.contributor.author Levitt, Naomi en_ZA
dc.contributor.author Lambert, Estelle en_ZA
dc.date.accessioned 2015-11-23T11:37:58Z
dc.date.available 2015-11-23T11:37:58Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Carstens, M. T., Goedecke, J. H., Dugas, L., Evans, J., Kroff, J., Levitt, N. S., & Lambert, E. V. (2013). Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility. Nutr Metab (Lond), 10(8). en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15221
dc.identifier.uri http://dx.doi.org/10.1186/1743-7075-10-8
dc.description.abstract BACKGROUND: Metabolic flexibility described as "the capacity of the body to match fuel oxidation to fuel availability" has been implicated in insulin resistance. We examined fasting substrate oxidation in relation to dietary macronutrient intake, and markers of insulin resistance in otherwise healthy women, with and without a family history of diabetes mellitus (FH DM). METHODS: We measured body composition (dual x-ray absorptiometry), visceral and subcutaneous adipose tissue area (VAT, SAT, using Computerised Tomography), fasting [glucose], [insulin], [free fatty acids], [blood lipids], insulin resistance (HOMA-IR), resting energy expenditure (REE), respiratory exchange ratio(RER) and self-reported physical activity in a convenience sample of 180 women (18-45 yrs). A food frequency questionnaire was used to assess energy intake (EI) and calculate the RER: Food Quotient (FQ) ratio. Only those with EI:REE (1.05 -2.28) were included (N=140). Insulin resistance was defined HOMA-IR (>1.95). RESULTS: The Insulin Resistant (IR) group had higher energy, carbohydrate and protein intakes (p<0.05) and lower PA levels than Insulin Sensitive (IS) group (P<0.001), but there were no differences in RER or RER:FQ between groups. However, nearly 50% of the variance in HOMA-IR was explained by age, body fat %, VAT, RER:FQ and FH DM (adjusted R2=0.50, p<0.0001). Insulin-resistant women, and those with FH DM had a higher RER:FQ than their counterparts (p<0.01), independent of body fat % or distribution. CONCLUSION: In these apparently healthy, weight-stable women, insulin resistance and FH DM were associated with lower fat oxidation in relation to dietary fat intake, suggesting lower metabolic flexibility. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Nutrition & Metabolism en_ZA
dc.source.uri http://nutritionandmetabolism.biomedcentral.com/ en_ZA
dc.subject.other HOMA-IR en_ZA
dc.subject.other Insulin-sensitivity en_ZA
dc.subject.other Dietary en_ZA
dc.subject.other fat intake en_ZA
dc.title Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility? en_ZA
dc.type Journal Article en_ZA
dc.rights.holder Carstens et al.; licensee BioMed Central Ltd. 2013 en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department MRC/UCT RU for Exercise and Sport Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Carstens, M., Goedecke, J., Dugas, L., Evans, J., Kroff, J., Levitt, N., & Lambert, E. (2013). Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility?. <i>Nutrition & Metabolism</i>, http://hdl.handle.net/11427/15221 en_ZA
dc.identifier.chicagocitation Carstens, Madelaine, Julia Goedecke, Lara Dugas, Juliet Evans, Jacolene Kroff, Naomi Levitt, and Estelle Lambert "Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility?." <i>Nutrition & Metabolism</i> (2013) http://hdl.handle.net/11427/15221 en_ZA
dc.identifier.vancouvercitation Carstens M, Goedecke J, Dugas L, Evans J, Kroff J, Levitt N, et al. Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility?. Nutrition & Metabolism. 2013; http://hdl.handle.net/11427/15221. en_ZA
dc.identifier.ris TY - Journal Article AU - Carstens, Madelaine AU - Goedecke, Julia AU - Dugas, Lara AU - Evans, Juliet AU - Kroff, Jacolene AU - Levitt, Naomi AU - Lambert, Estelle AB - BACKGROUND: Metabolic flexibility described as "the capacity of the body to match fuel oxidation to fuel availability" has been implicated in insulin resistance. We examined fasting substrate oxidation in relation to dietary macronutrient intake, and markers of insulin resistance in otherwise healthy women, with and without a family history of diabetes mellitus (FH DM). METHODS: We measured body composition (dual x-ray absorptiometry), visceral and subcutaneous adipose tissue area (VAT, SAT, using Computerised Tomography), fasting [glucose], [insulin], [free fatty acids], [blood lipids], insulin resistance (HOMA-IR), resting energy expenditure (REE), respiratory exchange ratio(RER) and self-reported physical activity in a convenience sample of 180 women (18-45 yrs). A food frequency questionnaire was used to assess energy intake (EI) and calculate the RER: Food Quotient (FQ) ratio. Only those with EI:REE (1.05 -2.28) were included (N=140). Insulin resistance was defined HOMA-IR (>1.95). RESULTS: The Insulin Resistant (IR) group had higher energy, carbohydrate and protein intakes (p<0.05) and lower PA levels than Insulin Sensitive (IS) group (P<0.001), but there were no differences in RER or RER:FQ between groups. However, nearly 50% of the variance in HOMA-IR was explained by age, body fat %, VAT, RER:FQ and FH DM (adjusted R2=0.50, p<0.0001). Insulin-resistant women, and those with FH DM had a higher RER:FQ than their counterparts (p<0.01), independent of body fat % or distribution. CONCLUSION: In these apparently healthy, weight-stable women, insulin resistance and FH DM were associated with lower fat oxidation in relation to dietary fat intake, suggesting lower metabolic flexibility. DA - 2013 DB - OpenUCT DO - 10.1186/1743-7075-10-8 DP - University of Cape Town J1 - Nutrition & Metabolism LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility? TI - Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility? UR - http://hdl.handle.net/11427/15221 ER - en_ZA


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