The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System

 

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dc.contributor.author Basson, Abigail en_ZA
dc.contributor.author Swart, Rina en_ZA
dc.contributor.author Jordaan, Esme en_ZA
dc.contributor.author Mazinu, Mikateko en_ZA
dc.contributor.author Watermeyer, Gillian en_ZA
dc.date.accessioned 2015-11-18T07:11:46Z
dc.date.available 2015-11-18T07:11:46Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Basson, A., Swart, R., Jordaan, E., Mazinu, M., & Watermeyer, G. (2013). The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System. PloS one, 9(8), e104859. doi:10.1371/journal.pone.0104859 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15143
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0104859
dc.description.abstract BACKGROUND: Inter-racial differences in disease characteristics and in the management of Crohn's disease (CD) have been described in African American and Asian subjects, however for the racial groups in South Africa, no such recent literature exists. METHODS: A cross sectional study of all consecutive CD patients seen at 2 large inflammatory bowel disease (IBD) referral centers in the Western Cape, South Africa between September 2011 and January 2013 was performed. Numerous demographic and clinical variables at diagnosis and date of study enrolment were identified using an investigator administered questionnaire as well as clinical examination and patient case notes. Using predefined definitions, disease behavior was stratified as ‘complicated’ or ‘uncomplicated’. RESULTS: One hundred and ninety four CD subjects were identified; 35 (18%) were white, 152 (78%) were Cape Coloured and 7(4%) were black. On multiple logistic regression analysis Cape Coloureds were significantly more likely to develop ‘complicated’ CD (60% vs. 9%, p = 0.023) during the disease course when compared to white subjects. In addition, significantly more white subjects had successfully discontinued cigarette smoking at study enrolment (31% vs. 7% reduction, p = 0.02). No additional inter-racial differences were found. A low proportion of IBD family history was observed among the non-white subjects. CONCLUSIONS: Cape Coloured patients were significantly more likely to develop ‘complicated’ CD over time when compared to whites. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Natural history of disease en_ZA
dc.subject.other South Africa en_ZA
dc.subject.other Tuberculosis diagnosis and management en_ZA
dc.subject.other Inflammatory bowel disease en_ZA
dc.subject.other Ethnic epidemiology en_ZA
dc.subject.other Demography en_ZA
dc.subject.other Smoking habits en_ZA
dc.subject.other Crohn's disease en_ZA
dc.title The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2014 Basson et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.