USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions

 

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dc.contributor.author Baron, Yorann en_ZA
dc.contributor.author Corre, Sébastien en_ZA
dc.contributor.author Mouchet, Nicolas en_ZA
dc.contributor.author Vaulont, Sophie en_ZA
dc.contributor.author Prince, Sharon en_ZA
dc.contributor.author Galibert, Marie-Dominique en_ZA
dc.date.accessioned 2015-11-18T07:10:41Z
dc.date.available 2015-11-18T07:10:41Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Baron, Y., Corre, S., Mouchet, N., Vaulont, S., Prince, S., & Galibert, M. D. (2012). USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. PLoS Genet, 8(1), 26. doi:10.1371/journal.pgen.1002470 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15138
dc.identifier.uri http://dx.doi.org/10.1371/journal.pgen.1002470
dc.description.abstract Author Summary UV is responsible for DNA damage and genetic alterations of key players of the Nucleotide Excision Repair (NER) machinery promote the development of UV-induced skin cancers. The NER is the major DNA-repair process involved in the recognition and removal of UV-mediated DNA damage. Different factors participating in this DNA repair are essential, and their mutations are associated with severe genetic diseases such as Cockayne Syndrome and Xeroderma Pigmentosum. Here, we show for the first time that the specific regulation of expression in response to UV of two NER factors CSA and HR23A is required to efficiently remove DNA lesions and to maintain genomic stability. We also implicate the USF-1 transcription factor in the regulation of the expression of these factors using in vitro and in vivo models. This finding is particularly important because UV is the major cause of skin cancers and dramatically compromises patients with highly sensitive genetic diseases. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLOS Genetics en_ZA
dc.source.uri http://journals.plos.org/plosgenetics en_ZA
dc.subject.other Gene expression en_ZA
dc.subject.other DNA damage en_ZA
dc.subject.other Keratinocytes en_ZA
dc.subject.other Gene regulation en_ZA
dc.subject.other Small interfering RNAs en_ZA
dc.subject.other Transcription factors en_ZA
dc.subject.other DNA repair en_ZA
dc.subject.other Immunoprecipitation en_ZA
dc.title USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2012 Baron et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Human Biology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Baron, Y., Corre, S., Mouchet, N., Vaulont, S., Prince, S., & Galibert, M. (2012). USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. <i>PLOS Genetics</i>, http://hdl.handle.net/11427/15138 en_ZA
dc.identifier.chicagocitation Baron, Yorann, Sébastien Corre, Nicolas Mouchet, Sophie Vaulont, Sharon Prince, and Marie-Dominique Galibert "USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions." <i>PLOS Genetics</i> (2012) http://hdl.handle.net/11427/15138 en_ZA
dc.identifier.vancouvercitation Baron Y, Corre S, Mouchet N, Vaulont S, Prince S, Galibert M. USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. PLOS Genetics. 2012; http://hdl.handle.net/11427/15138. en_ZA
dc.identifier.ris TY - Journal Article AU - Baron, Yorann AU - Corre, Sébastien AU - Mouchet, Nicolas AU - Vaulont, Sophie AU - Prince, Sharon AU - Galibert, Marie-Dominique AB - Author Summary UV is responsible for DNA damage and genetic alterations of key players of the Nucleotide Excision Repair (NER) machinery promote the development of UV-induced skin cancers. The NER is the major DNA-repair process involved in the recognition and removal of UV-mediated DNA damage. Different factors participating in this DNA repair are essential, and their mutations are associated with severe genetic diseases such as Cockayne Syndrome and Xeroderma Pigmentosum. Here, we show for the first time that the specific regulation of expression in response to UV of two NER factors CSA and HR23A is required to efficiently remove DNA lesions and to maintain genomic stability. We also implicate the USF-1 transcription factor in the regulation of the expression of these factors using in vitro and in vivo models. This finding is particularly important because UV is the major cause of skin cancers and dramatically compromises patients with highly sensitive genetic diseases. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pgen.1002470 DP - University of Cape Town J1 - PLOS Genetics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions TI - USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions UR - http://hdl.handle.net/11427/15138 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.