The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa

 

Show simple item record

dc.contributor.author Basson, Abigail en_ZA
dc.contributor.author Swart, Rina en_ZA
dc.contributor.author Jordaan, Esme en_ZA
dc.contributor.author Mazinu, Mikateko en_ZA
dc.contributor.author Watermeyer, Gillian en_ZA
dc.date.accessioned 2015-11-18T07:06:26Z
dc.date.available 2015-11-18T07:06:26Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Basson, A., Swart, R., Jordaan, E., Mazinu, M., & Watermeyer, G. (2014). The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa. PloS one, 9(12), e115492. doi:10.1371/journal.pone.0115492 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15117
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0115492
dc.description.abstract BACKGROUND: Environmental factors during childhood are thought to play a role in the aetiolgy of Crohn's Disease (CD). However the association between age at time of exposure and the subsequent development of CD in South Africa is unknown. METHODS: A case control study of all consecutive CD patients seen at 2 large inflammatory bowel disease (IBD) referral centers in the Western Cape, South Africa between September 2011 and January 2013 was performed. Numerous environmental exposures during 3 age intervals; 0-5, 6-10 and 11-18 years were extracted using an investigator administered questionnaire. An agreement analysis was performed to determine the reliability of questionnaire data for all the relevant variables. RESULTS: This study included 194 CD patients and 213 controls. On multiple logistic regression analysis, a number of childhood environmental exposures during the 3 age interval were significantly associated with the risk of developing CD. During the age interval 6-10 years, never having had consumed unpasteurized milk (OR = 5.84; 95% CI, 2.73-13.53) and never having a donkey, horse, sheep or cow on the property (OR = 2.48; 95% CI, 1.09-5.98) significantly increased the risk of developing future CD. During the age interval 11-18 years, an independent risk-association was identified for; never having consumed unpasteurized milk (OR = 2.60; 95% CI, 1.17-6.10) and second-hand cigarette smoke exposure (OR = 1.93; 95% CI, 1.13-3.35). CONCLUSION: This study demonstrates that both limited microbial exposures and exposure to second-hand cigarette smoke during childhood is associated with future development of CD. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Smoking habits en_ZA
dc.subject.other Milk en_ZA
dc.subject.other Smoking related disorders en_ZA
dc.subject.other Asses en_ZA
dc.subject.other Horses en_ZA
dc.subject.other Questionnaires en_ZA
dc.subject.other Sheep en_ZA
dc.subject.other Microbiome en_ZA
dc.title The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2014 Basson et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Surgical Gastroenterology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Basson, A., Swart, R., Jordaan, E., Mazinu, M., & Watermeyer, G. (2014). The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/15117 en_ZA
dc.identifier.chicagocitation Basson, Abigail, Rina Swart, Esme Jordaan, Mikateko Mazinu, and Gillian Watermeyer "The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa." <i>PLoS One</i> (2014) http://hdl.handle.net/11427/15117 en_ZA
dc.identifier.vancouvercitation Basson A, Swart R, Jordaan E, Mazinu M, Watermeyer G. The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa. PLoS One. 2014; http://hdl.handle.net/11427/15117. en_ZA
dc.identifier.ris TY - Journal Article AU - Basson, Abigail AU - Swart, Rina AU - Jordaan, Esme AU - Mazinu, Mikateko AU - Watermeyer, Gillian AB - BACKGROUND: Environmental factors during childhood are thought to play a role in the aetiolgy of Crohn's Disease (CD). However the association between age at time of exposure and the subsequent development of CD in South Africa is unknown. METHODS: A case control study of all consecutive CD patients seen at 2 large inflammatory bowel disease (IBD) referral centers in the Western Cape, South Africa between September 2011 and January 2013 was performed. Numerous environmental exposures during 3 age intervals; 0-5, 6-10 and 11-18 years were extracted using an investigator administered questionnaire. An agreement analysis was performed to determine the reliability of questionnaire data for all the relevant variables. RESULTS: This study included 194 CD patients and 213 controls. On multiple logistic regression analysis, a number of childhood environmental exposures during the 3 age interval were significantly associated with the risk of developing CD. During the age interval 6-10 years, never having had consumed unpasteurized milk (OR = 5.84; 95% CI, 2.73-13.53) and never having a donkey, horse, sheep or cow on the property (OR = 2.48; 95% CI, 1.09-5.98) significantly increased the risk of developing future CD. During the age interval 11-18 years, an independent risk-association was identified for; never having consumed unpasteurized milk (OR = 2.60; 95% CI, 1.17-6.10) and second-hand cigarette smoke exposure (OR = 1.93; 95% CI, 1.13-3.35). CONCLUSION: This study demonstrates that both limited microbial exposures and exposure to second-hand cigarette smoke during childhood is associated with future development of CD. DA - 2014 DB - OpenUCT DO - 10.1371/journal.pone.0115492 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa TI - The association between childhood environmental exposures and the subsequent development of Crohn's Disease in the Western Cape, South Africa UR - http://hdl.handle.net/11427/15117 ER - en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.