MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis

 

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dc.contributor.author Scott, Christiaan en_ZA
dc.contributor.author Kalla, Asgar en_ZA
dc.date.accessioned 2015-11-18T03:56:09Z
dc.date.available 2015-11-18T03:56:09Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Scott, C., & Kalla, A. (2011). MyastheniaGravis (MG) in a patient with Juvenile Idiopathic Arthritis. Pediatric Rheumatology, 9(Suppl 1), P185. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15067
dc.identifier.uri http://dx.doi.org/10.1186/1546-0096-9-S1-P185
dc.description.abstract Introduction; Myasthenia Gravis associated with Juvenile Idiopathic Arthritis has been reported in 5children with various subtypes of JIA [1,2]. Methods: We present a 17year old girl known with Rheumatoid Factor Positive Polyarticular Juvenile Idiopathic Arthritis for 4 years who developed Myasthenia Gravis while on therapy with Methotrexate, Prednisone and Ibuprofen. Results: This patient presented to the emergency room with a respiratory infection. She had been feeling weak and had noticed tongue weakness and difficulty swallowing, which had worsened significantly since the respiratory infection. On examination she was found to have clinical signs of Right Middle Lobe pneumonia and was found to be weak, especially in her proximal muscle groups. She had bilateral ptosis as well as facial weakness. She had active arthritis in multiple joints. Despite intravenous antibiotics and full supportive management she deteriorated rapidly, and within 12 hours required intubation and ventilation. The patient was found to have high ACH receptor antibodies and responded dramatically to pyridostygmine therapy, confirming the diagnosis of MG. High prednisone and azathioprine have been added to her regime. Discussion: Myasthenia Gravis is a rare association with JIA. The majority of cases appear to be associated with oligo-articular JIA. This patient presented after an acute infection and a recent worsening in her JIA symptoms. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Pediatric Rheumatology en_ZA
dc.source.uri http://www.ped-rheum.com/ en_ZA
dc.subject.other Myasthenia Gravis en_ZA
dc.title MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2011 Scott and Kalla; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Rheumatology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Scott, C., & Kalla, A. (2011). MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis. <i>Pediatric Rheumatology</i>, http://hdl.handle.net/11427/15067 en_ZA
dc.identifier.chicagocitation Scott, Christiaan, and Asgar Kalla "MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis." <i>Pediatric Rheumatology</i> (2011) http://hdl.handle.net/11427/15067 en_ZA
dc.identifier.vancouvercitation Scott C, Kalla A. MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis. Pediatric Rheumatology. 2011; http://hdl.handle.net/11427/15067. en_ZA
dc.identifier.ris TY - Journal Article AU - Scott, Christiaan AU - Kalla, Asgar AB - Introduction; Myasthenia Gravis associated with Juvenile Idiopathic Arthritis has been reported in 5children with various subtypes of JIA [1,2]. Methods: We present a 17year old girl known with Rheumatoid Factor Positive Polyarticular Juvenile Idiopathic Arthritis for 4 years who developed Myasthenia Gravis while on therapy with Methotrexate, Prednisone and Ibuprofen. Results: This patient presented to the emergency room with a respiratory infection. She had been feeling weak and had noticed tongue weakness and difficulty swallowing, which had worsened significantly since the respiratory infection. On examination she was found to have clinical signs of Right Middle Lobe pneumonia and was found to be weak, especially in her proximal muscle groups. She had bilateral ptosis as well as facial weakness. She had active arthritis in multiple joints. Despite intravenous antibiotics and full supportive management she deteriorated rapidly, and within 12 hours required intubation and ventilation. The patient was found to have high ACH receptor antibodies and responded dramatically to pyridostygmine therapy, confirming the diagnosis of MG. High prednisone and azathioprine have been added to her regime. Discussion: Myasthenia Gravis is a rare association with JIA. The majority of cases appear to be associated with oligo-articular JIA. This patient presented after an acute infection and a recent worsening in her JIA symptoms. DA - 2011 DB - OpenUCT DO - 10.1186/1546-0096-9-S1-P185 DP - University of Cape Town J1 - Pediatric Rheumatology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis TI - MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis UR - http://hdl.handle.net/11427/15067 ER - en_ZA


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