Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance

 

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dc.contributor.author Auger, Daniel en_ZA
dc.contributor.author Zhong, Xiaodong en_ZA
dc.contributor.author Epstein, Frederick en_ZA
dc.contributor.author Spottiswoode, Bruce en_ZA
dc.date.accessioned 2015-11-18T03:47:21Z
dc.date.available 2015-11-18T03:47:21Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Auger, D. A., Zhong, X., Epstein, F. H., & Spottiswoode, B. S. (2012). Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance. J Cardiovasc Magn Reson, 14(4). en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15049
dc.identifier.uri http://dx.doi.org/10.1186/1532-429X-14-4
dc.description.abstract BACKGROUND: The mechanics of the right ventricle (RV) are not well understood as studies of the RV have been limited. This is, in part, due to the RV's thin wall, asymmetric geometry and irregular motion. However, the RV plays an important role in cardiovascular function. This study aims to describe the complex mechanics of the healthy RV using three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR). METHODS: Whole heart 3D cine DENSE data were acquired from five healthy volunteers. Tailored post-processing algorithms for RV mid-wall tissue tracking and strain estimation are presented. A method for sub-dividing the RV into four regions according to anatomical land marks is proposed, and the temporal evolution of strain was assessed in these regions. RESULTS: The 3D cine DENSE tissue tracking methods successfully capture the motion and deformation of the RV at a high spatial resolution in all volunteers. The regional Lagrangian peak surface strain and time to peak values correspond with previous studies using myocardial tagging, DENSE and strain encoded CMR. The inflow region consistently displays lower peak strains than the apical and outflow regions, and the time to peak strains suggest RV mechanical activation in the following order: inflow, outflow, mid, then apex. CONCLUSIONS: Model-free techniques have been developed to study the myocardial mechanics of the RV at a high spatial resolution using 3D cine DENSE CMR. The consistency of the regional RV strain patterns across healthy subjects is encouraging and the techniques may have clinical utility in assessing disrupted RV mechanics in the diseased heart. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Journal of Cardiovascular Magnetic Resonance en_ZA
dc.source.uri http://www.jcmr-online.com/ en_ZA
dc.subject.other right ventricle (RV) en_ZA
dc.subject.other cardiovascular function en_ZA
dc.subject.other complex mechanics en_ZA
dc.subject.other healthy RV en_ZA
dc.title Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2012 Auger et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department MRC/UCT Medical Imaging Research Unit en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Auger, D., Zhong, X., Epstein, F., & Spottiswoode, B. (2012). Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance. <i>Journal of Cardiovascular Magnetic Resonance</i>, http://hdl.handle.net/11427/15049 en_ZA
dc.identifier.chicagocitation Auger, Daniel, Xiaodong Zhong, Frederick Epstein, and Bruce Spottiswoode "Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance." <i>Journal of Cardiovascular Magnetic Resonance</i> (2012) http://hdl.handle.net/11427/15049 en_ZA
dc.identifier.vancouvercitation Auger D, Zhong X, Epstein F, Spottiswoode B. Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance. 2012; http://hdl.handle.net/11427/15049. en_ZA
dc.identifier.ris TY - Journal Article AU - Auger, Daniel AU - Zhong, Xiaodong AU - Epstein, Frederick AU - Spottiswoode, Bruce AB - BACKGROUND: The mechanics of the right ventricle (RV) are not well understood as studies of the RV have been limited. This is, in part, due to the RV's thin wall, asymmetric geometry and irregular motion. However, the RV plays an important role in cardiovascular function. This study aims to describe the complex mechanics of the healthy RV using three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR). METHODS: Whole heart 3D cine DENSE data were acquired from five healthy volunteers. Tailored post-processing algorithms for RV mid-wall tissue tracking and strain estimation are presented. A method for sub-dividing the RV into four regions according to anatomical land marks is proposed, and the temporal evolution of strain was assessed in these regions. RESULTS: The 3D cine DENSE tissue tracking methods successfully capture the motion and deformation of the RV at a high spatial resolution in all volunteers. The regional Lagrangian peak surface strain and time to peak values correspond with previous studies using myocardial tagging, DENSE and strain encoded CMR. The inflow region consistently displays lower peak strains than the apical and outflow regions, and the time to peak strains suggest RV mechanical activation in the following order: inflow, outflow, mid, then apex. CONCLUSIONS: Model-free techniques have been developed to study the myocardial mechanics of the RV at a high spatial resolution using 3D cine DENSE CMR. The consistency of the regional RV strain patterns across healthy subjects is encouraging and the techniques may have clinical utility in assessing disrupted RV mechanics in the diseased heart. DA - 2012 DB - OpenUCT DO - 10.1186/1532-429X-14-4 DP - University of Cape Town J1 - Journal of Cardiovascular Magnetic Resonance LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance TI - Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance UR - http://hdl.handle.net/11427/15049 ER - en_ZA


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