Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study

 

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dc.contributor.author Sinxadi, Phumla Z
dc.contributor.author McIlleron, Helen M
dc.contributor.author Dave, Joel A
dc.contributor.author Smith, Peter J
dc.contributor.author Levitt, Naomi S
dc.contributor.author Maartens, Gary
dc.date.accessioned 2015-11-17T02:59:29Z
dc.date.available 2015-11-17T02:59:29Z
dc.date.issued 2012-10-26
dc.identifier.citation Sinxadi, P. Z., McIlleron, H. M., Dave, J. A., Smith, P. J., Levitt, N. S., & Maartens, G. (2012). Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study. AIDS research and therapy, 9(1), 1-6.
dc.identifier.uri http://hdl.handle.net/11427/15037
dc.identifier.uri http://dx.doi.org/10.1186/1742-6405-9-32
dc.description.abstract Abstract Background Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor in resource-limited settings, often causes dyslipidaemia. There are contradictory data regarding the association between lopinavir concentrations and changes in lipids. Aim To investigate associations between plasma lopinavir concentrations and lipid and glucose concentrations in HIV-infected South African adults. Methods Participants stable on lopinavir-based antiretroviral therapy were enrolled into a cross-sectional study. After an overnight fast, total cholesterol, triglycerides, and lopinavir concentrations were measured and an oral glucose tolerance test was performed. Regression analyses were used to determine associations between plasma lopinavir concentrations and fasting and 2 hour plasma glucose, fasting cholesterol, and triglycerides concentrations. Results There were 84 participants (72 women) with a median age of 36 years. The median blood pressure, body mass index and waist: hip ratio were 108/72 mmHg, 26 kg/m2 and 0.89 respectively. The median CD4 count was 478 cells/mm3. Median duration on lopinavir was 18.5 months. The median (interquartile range) lopinavir concentration was 8.0 (5.2 to 12.8) μg/mL. Regression analyses showed no significant association between lopinavir pre-dose concentrations and fasting cholesterol (β-coefficient −0.04 (95% CI −0.07 to 0.00)), triglycerides (β-coefficient −0.01 (95% CI −0.04 to 0.02)), fasting glucose (β-coefficient −0.01 (95% CI −0.04 to 0.02)), or 2-hour glucose concentrations (β-coefficient −0.02 (95% CI −0.09 to 0.06)). Lopinavir concentrations above the median were not associated with presence of dyslipidaemia or dysglycaemia. Conclusions There was no association between lopinavir plasma concentrations and plasma lipid and glucose concentrations.
dc.publisher BioMed Central Ltd
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.source AIDS research and therapy
dc.source.uri http://www.aidsrestherapy.com/
dc.subject.other Lopinavir en_ZA
dc.subject.other Hypercholesterolaemia en_ZA
dc.subject.other Hypertriglyceridaemia en_ZA
dc.subject.other Impaired glucose metabolism en_ZA
dc.subject.other Antiretroviral therapy en_ZA
dc.subject.other Pharmacokinetics en_ZA
dc.title Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study
dc.type Journal Article
dc.date.updated 2015-11-14T19:02:07Z
dc.language.rfc3066 en
dc.rights.holder Sinxadi et al.; licensee BioMed Central Ltd.
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Sinxadi, P. Z., McIlleron, H. M., Dave, J. A., Smith, P. J., Levitt, N. S., & Maartens, G. (2012). Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study. <i>AIDS research and therapy</i>, http://hdl.handle.net/11427/15037 en_ZA
dc.identifier.chicagocitation Sinxadi, Phumla Z, Helen M McIlleron, Joel A Dave, Peter J Smith, Naomi S Levitt, and Gary Maartens "Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study." <i>AIDS research and therapy</i> (2012) http://hdl.handle.net/11427/15037 en_ZA
dc.identifier.vancouvercitation Sinxadi PZ, McIlleron HM, Dave JA, Smith PJ, Levitt NS, Maartens G. Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study. AIDS research and therapy. 2012; http://hdl.handle.net/11427/15037. en_ZA
dc.identifier.ris TY - Journal Article AU - Sinxadi, Phumla Z AU - McIlleron, Helen M AU - Dave, Joel A AU - Smith, Peter J AU - Levitt, Naomi S AU - Maartens, Gary AB - Abstract Background Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor in resource-limited settings, often causes dyslipidaemia. There are contradictory data regarding the association between lopinavir concentrations and changes in lipids. Aim To investigate associations between plasma lopinavir concentrations and lipid and glucose concentrations in HIV-infected South African adults. Methods Participants stable on lopinavir-based antiretroviral therapy were enrolled into a cross-sectional study. After an overnight fast, total cholesterol, triglycerides, and lopinavir concentrations were measured and an oral glucose tolerance test was performed. Regression analyses were used to determine associations between plasma lopinavir concentrations and fasting and 2 hour plasma glucose, fasting cholesterol, and triglycerides concentrations. Results There were 84 participants (72 women) with a median age of 36 years. The median blood pressure, body mass index and waist: hip ratio were 108/72 mmHg, 26 kg/m2 and 0.89 respectively. The median CD4 count was 478 cells/mm3. Median duration on lopinavir was 18.5 months. The median (interquartile range) lopinavir concentration was 8.0 (5.2 to 12.8) μg/mL. Regression analyses showed no significant association between lopinavir pre-dose concentrations and fasting cholesterol (β-coefficient −0.04 (95% CI −0.07 to 0.00)), triglycerides (β-coefficient −0.01 (95% CI −0.04 to 0.02)), fasting glucose (β-coefficient −0.01 (95% CI −0.04 to 0.02)), or 2-hour glucose concentrations (β-coefficient −0.02 (95% CI −0.09 to 0.06)). Lopinavir concentrations above the median were not associated with presence of dyslipidaemia or dysglycaemia. Conclusions There was no association between lopinavir plasma concentrations and plasma lipid and glucose concentrations. DA - 2012-10-26 DB - OpenUCT DO - 10.1186/1742-6405-9-32 DP - University of Cape Town J1 - AIDS research and therapy LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study TI - Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study UR - http://hdl.handle.net/11427/15037 ER - en_ZA


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