Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts

 

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dc.contributor.author Davies, Anna en_ZA
dc.contributor.author Singh, Kasha P en_ZA
dc.contributor.author Shubber, Zara en_ZA
dc.contributor.author duCros, Philipp en_ZA
dc.contributor.author Mills, Edward J en_ZA
dc.contributor.author Cooke, Graham en_ZA
dc.contributor.author Ford, Nathan en_ZA
dc.date.accessioned 2015-11-16T04:09:41Z
dc.date.available 2015-11-16T04:09:41Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Davies, A., Singh, K. P., Shubber, Z., Ducros, P., Mills, E. J., Cooke, G., & Ford, N. (2013). Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts. PloS one, 8(2), e55373. doi:10.1371/journal.pone.0055373 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15005
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0055373
dc.description.abstract Introduction Co-infection with Hepatitis C (HCV) and HIV is common and HIV accelerates hepatic disease progression due to HCV. However, access to HCV treatment is limited and success rates are generally poor. METHODS: We conducted a systematic review and meta-analysis to assess HCV treatment outcomes in observational cohorts. Two databases (Medline and EMBASE) were searched using a compound search strategy for cohort studies reporting HCV treatment outcomes (as determined by a sustained virological response, SVR) in HIV-positive patients initiating HCV treatment for the first time. RESULTS: 40 studies were included for review, providing outcomes on 5339 patients from 17 countries. The pooled proportion of patients achieving SVR was 38%. Significantly poorer outcomes were observed for patients infected with HCV genotypes 1 or 4 (pooled SVR 24.5%), compared to genotypes 2 or 3 (pooled SVR 59.8%). The pooled proportion of patients who discontinued treatment due to drug toxicities (reported by 33 studies) was low, at 4.3% (3.3-5.3%). Defaulting from treatment, reported by 33 studies, was also low (5.1%, 3.5-6.6%), as was on-treatment mortality (35 studies, 0.1% (0-0.2%)). CONCLUSIONS: These results, reported under programmatic conditions, are comparable to those reported in randomised clinical trials, and show that although HCV treatment outcomes are generally poor in HIV co-infected patients, those infected with HCV genotypes 2 or 3 have outcomes comparable to HIV-negative patients. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Hepatitis C virus en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Drug therapy en_ZA
dc.subject.other Interferons en_ZA
dc.subject.other Highly-active antiretroviral therapy en_ZA
dc.title Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2013 Davies et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Davies, A., Singh, K. P., Shubber, Z., duCros, P., Mills, E. J., Cooke, G., & Ford, N. (2013). Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts. <i>PLoS One</i>, http://hdl.handle.net/11427/15005 en_ZA
dc.identifier.chicagocitation Davies, Anna, Kasha P Singh, Zara Shubber, Philipp duCros, Edward J Mills, Graham Cooke, and Nathan Ford "Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/15005 en_ZA
dc.identifier.vancouvercitation Davies A, Singh KP, Shubber Z, duCros P, Mills EJ, Cooke G, et al. Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts. PLoS One. 2013; http://hdl.handle.net/11427/15005. en_ZA
dc.identifier.ris TY - Journal Article AU - Davies, Anna AU - Singh, Kasha P AU - Shubber, Zara AU - duCros, Philipp AU - Mills, Edward J AU - Cooke, Graham AU - Ford, Nathan AB - Introduction Co-infection with Hepatitis C (HCV) and HIV is common and HIV accelerates hepatic disease progression due to HCV. However, access to HCV treatment is limited and success rates are generally poor. METHODS: We conducted a systematic review and meta-analysis to assess HCV treatment outcomes in observational cohorts. Two databases (Medline and EMBASE) were searched using a compound search strategy for cohort studies reporting HCV treatment outcomes (as determined by a sustained virological response, SVR) in HIV-positive patients initiating HCV treatment for the first time. RESULTS: 40 studies were included for review, providing outcomes on 5339 patients from 17 countries. The pooled proportion of patients achieving SVR was 38%. Significantly poorer outcomes were observed for patients infected with HCV genotypes 1 or 4 (pooled SVR 24.5%), compared to genotypes 2 or 3 (pooled SVR 59.8%). The pooled proportion of patients who discontinued treatment due to drug toxicities (reported by 33 studies) was low, at 4.3% (3.3-5.3%). Defaulting from treatment, reported by 33 studies, was also low (5.1%, 3.5-6.6%), as was on-treatment mortality (35 studies, 0.1% (0-0.2%)). CONCLUSIONS: These results, reported under programmatic conditions, are comparable to those reported in randomised clinical trials, and show that although HCV treatment outcomes are generally poor in HIV co-infected patients, those infected with HCV genotypes 2 or 3 have outcomes comparable to HIV-negative patients. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0055373 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts TI - Treatment outcomes of treatment-naïve Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts UR - http://hdl.handle.net/11427/15005 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.