Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho

 

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dc.contributor.author Bygrave, Helen en_ZA
dc.contributor.author Kranzer, Katharina en_ZA
dc.contributor.author Hilderbrand, Katherine en_ZA
dc.contributor.author Whittall, Jonathan en_ZA
dc.contributor.author Jouquet, Guillaume en_ZA
dc.contributor.author Goemaere, Eric en_ZA
dc.contributor.author Vlahakis, Nathalie en_ZA
dc.contributor.author Triviño, Laura en_ZA
dc.contributor.author Makakole, Lipontso en_ZA
dc.contributor.author Ford, Nathan en_ZA
dc.date.accessioned 2015-11-16T04:08:02Z
dc.date.available 2015-11-16T04:08:02Z
dc.date.issued 2010 en_ZA
dc.identifier.citation Bygrave, H., Kranzer, K., Hilderbrand, K., Whittall, J., Jouquet, G., Goemaere, E., ... & Ford, N. (2010). Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho. PLoS One, 5(10), e13198. doi:10.1371/journal.pone.0013198 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14984
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0013198
dc.description.abstract BACKGROUND: The provision of antiretroviral therapy (ART) to migrant populations raises particular challenges with respect to ensuring adequate treatment support, adherence, and retention in care. We assessed rates of loss to follow-up for migrant workers compared with non-migrant workers in a routine treatment programme in Morjia, Lesotho. Design All adult patients (≥18 years) initiating ART between January 1, 2008, and December 31, 2008, and followed up until the end of 2009, were included in the study. We described rates of loss to follow-up according to migrant status by Kaplan-Meier estimates, and used Poisson regression to model associations between migrant status and loss to follow-up controlling for potential confounders identified a priori. RESULTS: Our cohort comprised 1185 people, among whom 12% (148) were migrant workers. Among the migrant workers, median age was 36.1 (29.6-45.9) and the majority (55%) were male. We found no statistically significant differences between baseline characteristics and migrant status. Rates of lost to follow up were similar between migrants and non-migrants in the first 3 months but differences increased thereafter. Between 3 and 6 months after initiating antiretroviral therapy, migrants had a 2.78-fold increased rate of defaulting (95%CI 1.15-6.73); between 6 and 12 months the rate was 2.36 times greater (95%CI 1.18-4.73), whereas after 1 year the rate was 6.69 times greater (95%CI 3.18-14.09). CONCLUSIONS: Our study highlights the need for programme implementers to take into account the specific challenges that may influence continuity of antiretroviral treatment and care for migrant populations. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Labor mobility en_ZA
dc.subject.other Antiretroviral therapy en_ZA
dc.subject.other Lesotho en_ZA
dc.subject.other South Africa en_ZA
dc.subject.other AIDS en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Adults en_ZA
dc.subject.other Antiretrovirals en_ZA
dc.title Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2010 Bygrave et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Bygrave, H., Kranzer, K., Hilderbrand, K., Whittall, J., Jouquet, G., Goemaere, E., ... Ford, N. (2010). Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho. <i>PLoS One</i>, http://hdl.handle.net/11427/14984 en_ZA
dc.identifier.chicagocitation Bygrave, Helen, Katharina Kranzer, Katherine Hilderbrand, Jonathan Whittall, Guillaume Jouquet, Eric Goemaere, Nathalie Vlahakis, Laura Triviño, Lipontso Makakole, and Nathan Ford "Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho." <i>PLoS One</i> (2010) http://hdl.handle.net/11427/14984 en_ZA
dc.identifier.vancouvercitation Bygrave H, Kranzer K, Hilderbrand K, Whittall J, Jouquet G, Goemaere E, et al. Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho. PLoS One. 2010; http://hdl.handle.net/11427/14984. en_ZA
dc.identifier.ris TY - Journal Article AU - Bygrave, Helen AU - Kranzer, Katharina AU - Hilderbrand, Katherine AU - Whittall, Jonathan AU - Jouquet, Guillaume AU - Goemaere, Eric AU - Vlahakis, Nathalie AU - Triviño, Laura AU - Makakole, Lipontso AU - Ford, Nathan AB - BACKGROUND: The provision of antiretroviral therapy (ART) to migrant populations raises particular challenges with respect to ensuring adequate treatment support, adherence, and retention in care. We assessed rates of loss to follow-up for migrant workers compared with non-migrant workers in a routine treatment programme in Morjia, Lesotho. Design All adult patients (≥18 years) initiating ART between January 1, 2008, and December 31, 2008, and followed up until the end of 2009, were included in the study. We described rates of loss to follow-up according to migrant status by Kaplan-Meier estimates, and used Poisson regression to model associations between migrant status and loss to follow-up controlling for potential confounders identified a priori. RESULTS: Our cohort comprised 1185 people, among whom 12% (148) were migrant workers. Among the migrant workers, median age was 36.1 (29.6-45.9) and the majority (55%) were male. We found no statistically significant differences between baseline characteristics and migrant status. Rates of lost to follow up were similar between migrants and non-migrants in the first 3 months but differences increased thereafter. Between 3 and 6 months after initiating antiretroviral therapy, migrants had a 2.78-fold increased rate of defaulting (95%CI 1.15-6.73); between 6 and 12 months the rate was 2.36 times greater (95%CI 1.18-4.73), whereas after 1 year the rate was 6.69 times greater (95%CI 3.18-14.09). CONCLUSIONS: Our study highlights the need for programme implementers to take into account the specific challenges that may influence continuity of antiretroviral treatment and care for migrant populations. DA - 2010 DB - OpenUCT DO - 10.1371/journal.pone.0013198 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho TI - Trends in loss to follow-up among migrant workers on antiretroviral therapy in a community cohort in Lesotho UR - http://hdl.handle.net/11427/14984 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.