The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas

 

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dc.contributor.author London, Leslie en_ZA
dc.contributor.author Coggon, David en_ZA
dc.contributor.author Moretto, Angelo en_ZA
dc.contributor.author Westerholm, Peter en_ZA
dc.contributor.author Wilks, Martin en_ZA
dc.contributor.author Colosio, Claudio en_ZA
dc.date.accessioned 2015-11-11T12:03:50Z
dc.date.available 2015-11-11T12:03:50Z
dc.date.issued 2010 en_ZA
dc.identifier.citation London, L., Coggon, D., Moretto, A., Westerholm, P., Wilks, M. F., & Colosio, C. (2010). The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas. Environmental health, 9(1), 50-66. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14907
dc.identifier.uri http://dx.doi.org/10.1186/1476-069X-9-50
dc.description.abstract The controversy about the use of data from human volunteer studies involving experimental exposure to pesticides as part of regulatory risk assessment has been widely discussed, but the complex and interrelated scientific and ethical issues remain largely unresolved. This discussion paper, generated by authors who comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews the use of human experimental studies in regulatory risk assessment for pesticides with a view to advancing the debate as to when, if ever, such studies might be ethically justifiable. The discussion is based on three elements: (a) a review of discussion papers on the topic of human testing of pesticides and the positions adopted by regulatory agencies in developed countries; (b) an analysis of published and unpublished studies involving human testing with pesticides, both in the peer-reviewed literature and in the JMPR database; and (c) application of an ethical analysis to the problem. The paper identifies areas of agreement which include general principles that may provide a starting point on which to base criteria for judgements as to the ethical acceptability of such studies. However, the paper also highlights ongoing unresolved differences of opinion inherent in ethical analysis of contentious issues, which we propose should form a starting point for further debate and the development of guidelines to achieve better resolution of this matter. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Environmental Health en_ZA
dc.source.uri http://www.ehjournal.net/ en_ZA
dc.subject.other Biomedical Research en_ZA
dc.subject.other Environmental Exposure en_ZA
dc.subject.other Ethics, Research en_ZA
dc.subject.other Pesticides en_ZA
dc.title The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2010 London et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Occupational and Environmental Health RU en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License