Outcome of HIV-exposed uninfected children undergoing surgery

 

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dc.contributor.author Karpelowsky, Jonathan en_ZA
dc.contributor.author Millar, Alastair en_ZA
dc.contributor.author van der Graaf, Nelleke en_ZA
dc.contributor.author van Bogerijen, Guido en_ZA
dc.contributor.author Zar, Heather en_ZA
dc.date.accessioned 2015-10-30T09:30:19Z
dc.date.available 2015-10-30T09:30:19Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Karpelowsky, J. S., Millar, A. J., van der Graaf, N., van Bogerijen, G., & Zar, H. J. (2011). Outcome of HIV-exposed uninfected children undergoing surgery. BMC pediatrics, 11(1), 69. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14507
dc.identifier.uri http://dx.doi.org/10.1186/1471-2431-11-69
dc.description.abstract BACKGROUND:HIV-exposed uninfected (HIVe) children are a rapidly growing population that may be at an increased risk of illness compared to HIV-unexposed children (HIVn). The aim of this study was to investigate the morbidity and mortality of HIVe compared to both HIVn and HIV-infected (HIVi) children after a general surgical procedure. METHODS: A prospective study of children less than 60 months of age undergoing general surgery at a paediatric referral hospital from July 2004 to July 2008 inclusive. Children underwent age-definitive HIV testing and were followed up post operatively for the development of complications, length of stay and mortality. RESULTS: Three hundred and eighty children were enrolled; 4 died and 11 were lost to follow up prior to HIV testing, thus 365 children were included. Of these, 38(10.4%) were HIVe, 245(67.1%) were HIVn and 82(22.5%) were HIVi children.The overall mortality was low, with 2(5.2%) deaths in the HIVe group, 0 in the HIVn group and 6(7.3%) in the HIVi group (p = 0.0003). HIVe had a longer stay than HIVn children (3 (2-7) vs. 2 (1-4) days p = 0.02). There was no significant difference in length of stay between the HIVe and HIVi groups. HIVe children had a higher rate of complications compared to HIVn children, (9 (23.7%) vs. 14(5.7%) (RR 3.8(2.1-7) p < 0.0001) but a similar rate of complications compared to HIVi children 34 (41.5%) (RR = 0.6 (0.3-1.1) p = 0.06). CONCLUSION: HIVe children have a higher risk of developing complications and mortality after surgery compared to HIVn children. However, the risk of complications is lower than that of HIVi children. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source BMC Pediatrics en_ZA
dc.source.uri http://www.biomedcentral.com/bmcpediatr/ en_ZA
dc.subject.other HIV Infections en_ZA
dc.subject.other Hospital Mortality en_ZA
dc.subject.other Infectious Disease Transmission en_ZA
dc.title Outcome of HIV-exposed uninfected children undergoing surgery en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2011 Karpelowsky et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Paediatric Surgery en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Karpelowsky, J., Millar, A., van der Graaf, N., van Bogerijen, G., & Zar, H. (2011). Outcome of HIV-exposed uninfected children undergoing surgery. <i>BMC Pediatrics</i>, http://hdl.handle.net/11427/14507 en_ZA
dc.identifier.chicagocitation Karpelowsky, Jonathan, Alastair Millar, Nelleke van der Graaf, Guido van Bogerijen, and Heather Zar "Outcome of HIV-exposed uninfected children undergoing surgery." <i>BMC Pediatrics</i> (2011) http://hdl.handle.net/11427/14507 en_ZA
dc.identifier.vancouvercitation Karpelowsky J, Millar A, van der Graaf N, van Bogerijen G, Zar H. Outcome of HIV-exposed uninfected children undergoing surgery. BMC Pediatrics. 2011; http://hdl.handle.net/11427/14507. en_ZA
dc.identifier.ris TY - Journal Article AU - Karpelowsky, Jonathan AU - Millar, Alastair AU - van der Graaf, Nelleke AU - van Bogerijen, Guido AU - Zar, Heather AB - BACKGROUND:HIV-exposed uninfected (HIVe) children are a rapidly growing population that may be at an increased risk of illness compared to HIV-unexposed children (HIVn). The aim of this study was to investigate the morbidity and mortality of HIVe compared to both HIVn and HIV-infected (HIVi) children after a general surgical procedure. METHODS: A prospective study of children less than 60 months of age undergoing general surgery at a paediatric referral hospital from July 2004 to July 2008 inclusive. Children underwent age-definitive HIV testing and were followed up post operatively for the development of complications, length of stay and mortality. RESULTS: Three hundred and eighty children were enrolled; 4 died and 11 were lost to follow up prior to HIV testing, thus 365 children were included. Of these, 38(10.4%) were HIVe, 245(67.1%) were HIVn and 82(22.5%) were HIVi children.The overall mortality was low, with 2(5.2%) deaths in the HIVe group, 0 in the HIVn group and 6(7.3%) in the HIVi group (p = 0.0003). HIVe had a longer stay than HIVn children (3 (2-7) vs. 2 (1-4) days p = 0.02). There was no significant difference in length of stay between the HIVe and HIVi groups. HIVe children had a higher rate of complications compared to HIVn children, (9 (23.7%) vs. 14(5.7%) (RR 3.8(2.1-7) p < 0.0001) but a similar rate of complications compared to HIVi children 34 (41.5%) (RR = 0.6 (0.3-1.1) p = 0.06). CONCLUSION: HIVe children have a higher risk of developing complications and mortality after surgery compared to HIVn children. However, the risk of complications is lower than that of HIVi children. DA - 2011 DB - OpenUCT DO - 10.1186/1471-2431-11-69 DP - University of Cape Town J1 - BMC Pediatrics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Outcome of HIV-exposed uninfected children undergoing surgery TI - Outcome of HIV-exposed uninfected children undergoing surgery UR - http://hdl.handle.net/11427/14507 ER - en_ZA


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