A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus

 

Show simple item record

dc.contributor.author Tiffin, Nicki en_ZA
dc.contributor.author Adeyemo, Adebowale en_ZA
dc.contributor.author Okpechi, Ikechi en_ZA
dc.date.accessioned 2015-10-30T09:27:34Z
dc.date.available 2015-10-30T09:27:34Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Tiffin, N., Adeyemo, A., & Okpechi, I. (2013). A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus. Orphanet J Rare Dis, 8(2). en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14499
dc.identifier.uri http://dx.doi.org/10.1186/1750-1172-8-2
dc.description.abstract Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening when major organs are involved. The full pathological and genetic mechanisms of this complex disease are yet to be elucidated; although roles have been described for environmental triggers such as sunlight, drugs and chemicals, and infectious agents. Cellular processes such as inefficient clearing of apoptotic DNA fragments and generation of autoantibodies have been implicated in disease progression. A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have also been identified; and an effect of ethnicity on susceptibility has been described. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Orphanet Journal of Rare Diseases en_ZA
dc.source.uri http://www.ojrd.com/ en_ZA
dc.subject.other Systemic lupus erythematosus en_ZA
dc.subject.other Autoimmunity en_ZA
dc.subject.other Genetic susceptibility en_ZA
dc.subject.other Apoptosis en_ZA
dc.subject.other dsDNA en_ZA
dc.subject.other Disease genes en_ZA
dc.title A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2013 Tiffin et al.; licensee BioMed Central Ltd en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Nephrology and Hypertension en_ZA
uct.type.filetype Text
uct.type.filetype Image


Files in this item

This item appears in the following Collection(s)

Show simple item record

This is an open access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License