Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans

 

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dc.contributor.author Chatterjee, Koushik en_ZA
dc.contributor.author Engelmark, Malin en_ZA
dc.contributor.author Gyllensten, Ulf en_ZA
dc.contributor.author Dandara, Collet en_ZA
dc.contributor.author Merwe, Lize en_ZA
dc.contributor.author Galal, Ushma en_ZA
dc.contributor.author Hoffman, Margaret en_ZA
dc.contributor.author Williamson, Anna-Lise en_ZA
dc.date.accessioned 2015-10-30T09:25:53Z
dc.date.available 2015-10-30T09:25:53Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Chatterjee, K., Engelmark, M., Gyllensten, U., Dandara, C., van der Merwe, L., Galal, U., ... & Williamson, A. L. (2009). Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans. BMC research notes, 2(1), 238. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14493
dc.identifier.uri http://dx.doi.org/10.1186/1756-0500-2-238
dc.description.abstract BACKGROUND:Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated whether these polymorphisms are associated with cervical cancer or human papillomavirus (HPV) infection in South African women.FINDINGS:Participants were 447 women with invasive cervical cancer (106 black African and 341 women of mixed-ancestry) and 424 healthy women controls, matched by age, (101 black African and 323 women of mixed-ancestry) and domicile (rural or urban). Two polymorphisms in Fas gene (FasR-1377G/A, FasR-670A/G) and one in FasL gene (FasL844T/C) were genotyped by TaqMan. None of the polymorphisms, or the Fas haplotypes, showed a significant association with cervical cancer. There was also no association with HPV infection in the control group. However, on analysis of the control group, highly significant allele, genotype and haplotype differences were found between the two ethnic groups. There were generally low frequencies of FasR-1377A alleles, FasR-670A alleles and FasL-844C alleles in black women compared to the women of mixed-ancestry. CONCLUSION: This is the first study on the role of Fas and FasL polymorphisms in cervical cancer in African populations. Our results suggest that these SNPs are not associated with cervical cancer in these populations. The allele frequencies of the three SNPs differed markedly between the indigenous African black and mixed-ancestry populations. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source BMC Research Notes en_ZA
dc.source.uri http://www.biomedcentral.com/bmcresnotes/ en_ZA
dc.subject.other Cervical cancer en_ZA
dc.subject.other Human Papillomavirus en_ZA
dc.subject.other Gene Polymorphism en_ZA
dc.title Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2009 Williamson et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Virology en_ZA
uct.type.filetype Text
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License