dc.contributor.author |
Chatterjee, Koushik
|
en_ZA |
dc.contributor.author |
Engelmark, Malin
|
en_ZA |
dc.contributor.author |
Gyllensten, Ulf
|
en_ZA |
dc.contributor.author |
Dandara, Collet
|
en_ZA |
dc.contributor.author |
Merwe, Lize
|
en_ZA |
dc.contributor.author |
Galal, Ushma
|
en_ZA |
dc.contributor.author |
Hoffman, Margaret
|
en_ZA |
dc.contributor.author |
Williamson, Anna-Lise
|
en_ZA |
dc.date.accessioned |
2015-10-30T09:25:53Z |
|
dc.date.available |
2015-10-30T09:25:53Z |
|
dc.date.issued |
2009 |
en_ZA |
dc.identifier.citation |
Chatterjee, K., Engelmark, M., Gyllensten, U., Dandara, C., van der Merwe, L., Galal, U., ... & Williamson, A. L. (2009). Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans. BMC research notes, 2(1), 238. |
en_ZA |
dc.identifier.uri |
http://hdl.handle.net/11427/14493
|
|
dc.identifier.uri |
http://dx.doi.org/10.1186/1756-0500-2-238
|
|
dc.description.abstract |
BACKGROUND:Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated whether these polymorphisms are associated with cervical cancer or human papillomavirus (HPV) infection in South African women.FINDINGS:Participants were 447 women with invasive cervical cancer (106 black African and 341 women of mixed-ancestry) and 424 healthy women controls, matched by age, (101 black African and 323 women of mixed-ancestry) and domicile (rural or urban). Two polymorphisms in Fas gene (FasR-1377G/A, FasR-670A/G) and one in FasL gene (FasL844T/C) were genotyped by TaqMan. None of the polymorphisms, or the Fas haplotypes, showed a significant association with cervical cancer. There was also no association with HPV infection in the control group. However, on analysis of the control group, highly significant allele, genotype and haplotype differences were found between the two ethnic groups. There were generally low frequencies of FasR-1377A alleles, FasR-670A alleles and FasL-844C alleles in black women compared to the women of mixed-ancestry. CONCLUSION: This is the first study on the role of Fas and FasL polymorphisms in cervical cancer in African populations. Our results suggest that these SNPs are not associated with cervical cancer in these populations. The allele frequencies of the three SNPs differed markedly between the indigenous African black and mixed-ancestry populations. |
en_ZA |
dc.language.iso |
eng |
en_ZA |
dc.publisher |
BioMed Central Ltd |
en_ZA |
dc.rights |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License |
en_ZA |
dc.rights.uri |
http://creativecommons.org/licenses/by/2.0 |
en_ZA |
dc.source |
BMC Research Notes |
en_ZA |
dc.source.uri |
http://www.biomedcentral.com/bmcresnotes/
|
en_ZA |
dc.subject.other |
Cervical cancer |
en_ZA |
dc.subject.other |
Human Papillomavirus |
en_ZA |
dc.subject.other |
Gene Polymorphism |
en_ZA |
dc.title |
Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans |
en_ZA |
dc.type |
Journal Article |
en_ZA |
dc.rights.holder |
2009 Williamson et al; licensee BioMed Central Ltd. |
en_ZA |
uct.type.publication |
Research |
en_ZA |
uct.type.resource |
Article
|
en_ZA |
dc.publisher.institution |
University of Cape Town |
|
dc.publisher.faculty |
Faculty of Health Sciences |
en_ZA |
dc.publisher.department |
Division of Virology |
en_ZA |
uct.type.filetype |
Text |
|
uct.type.filetype |
Image |
|
dc.identifier.apacitation |
Chatterjee, K., Engelmark, M., Gyllensten, U., Dandara, C., Merwe, L., Galal, U., ... Williamson, A. (2009). Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans. <i>BMC Research Notes</i>, http://hdl.handle.net/11427/14493 |
en_ZA |
dc.identifier.chicagocitation |
Chatterjee, Koushik, Malin Engelmark, Ulf Gyllensten, Collet Dandara, Lize Merwe, Ushma Galal, Margaret Hoffman, and Anna-Lise Williamson "Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans." <i>BMC Research Notes</i> (2009) http://hdl.handle.net/11427/14493 |
en_ZA |
dc.identifier.vancouvercitation |
Chatterjee K, Engelmark M, Gyllensten U, Dandara C, Merwe L, Galal U, et al. Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans. BMC Research Notes. 2009; http://hdl.handle.net/11427/14493. |
en_ZA |
dc.identifier.ris |
TY - Journal Article
AU - Chatterjee, Koushik
AU - Engelmark, Malin
AU - Gyllensten, Ulf
AU - Dandara, Collet
AU - Merwe, Lize
AU - Galal, Ushma
AU - Hoffman, Margaret
AU - Williamson, Anna-Lise
AB - BACKGROUND:Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated whether these polymorphisms are associated with cervical cancer or human papillomavirus (HPV) infection in South African women.FINDINGS:Participants were 447 women with invasive cervical cancer (106 black African and 341 women of mixed-ancestry) and 424 healthy women controls, matched by age, (101 black African and 323 women of mixed-ancestry) and domicile (rural or urban). Two polymorphisms in Fas gene (FasR-1377G/A, FasR-670A/G) and one in FasL gene (FasL844T/C) were genotyped by TaqMan. None of the polymorphisms, or the Fas haplotypes, showed a significant association with cervical cancer. There was also no association with HPV infection in the control group. However, on analysis of the control group, highly significant allele, genotype and haplotype differences were found between the two ethnic groups. There were generally low frequencies of FasR-1377A alleles, FasR-670A alleles and FasL-844C alleles in black women compared to the women of mixed-ancestry. CONCLUSION: This is the first study on the role of Fas and FasL polymorphisms in cervical cancer in African populations. Our results suggest that these SNPs are not associated with cervical cancer in these populations. The allele frequencies of the three SNPs differed markedly between the indigenous African black and mixed-ancestry populations.
DA - 2009
DB - OpenUCT
DO - 10.1186/1756-0500-2-238
DP - University of Cape Town
J1 - BMC Research Notes
LK - https://open.uct.ac.za
PB - University of Cape Town
PY - 2009
T1 - Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
TI - Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
UR - http://hdl.handle.net/11427/14493
ER -
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en_ZA |