IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections

 

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dc.contributor.author Marillier, Reece en_ZA
dc.contributor.author Michels, Chesney en_ZA
dc.contributor.author Smith, Elizabeth en_ZA
dc.contributor.author Fick, Lizette en_ZA
dc.contributor.author Leeto, Mosiuoa en_ZA
dc.contributor.author Dewals, Benjamin en_ZA
dc.contributor.author Horsnell, William en_ZA
dc.contributor.author Brombacher, Frank en_ZA
dc.date.accessioned 2015-10-28T07:04:56Z
dc.date.available 2015-10-28T07:04:56Z
dc.date.issued 2008 en_ZA
dc.identifier.citation Marillier, R. G., Michels, C., Smith, E. M., Fick, L. C., Leeto, M., Dewals, B., ... & Brombacher, F. (2008). IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC immunology, 9(1), 11. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14469
dc.identifier.uri http://dx.doi.org/10.1186/1471-2172-9-11
dc.description.abstract BACKGROUND: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is associated with TH2 immune responses, which in helminth infections are controlled primarily by IL-13, and also IL-4. In the study presented here we examine the goblet cell hyperplasic response to three experimental parasitic helminth infections; namely Nippostrongylus brasiliensis, Syphacia obvelata and Schistosoma mansoni. RESULTS: As expected N. brasiliensis infection induced a strong goblet cell hyperplasia dependent on IL-4/IL-13/IL-4Ralpha expression. In contrast, and despite previously published transiently elevated IL-4/IL-13 levels, S. obvelata infections did not increase goblet cell hyperplasia in the colon. Furthermore, induction of goblet cell hyperplasia in response to S. mansoni eggs traversing the intestine was equivalent between BALB/c, IL-4/IL-13-/- and IL-4Ralpha-/- mice. CONCLUSION: Together these data demonstrate that intestinal goblet cell hyperplasia can be independent of TH2 immune responses associated with parasitic helminth infections. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ en_ZA
dc.source BMC Immunology en_ZA
dc.source.uri http://www.biomedcentral.com/bmcimmunol/ en_ZA
dc.subject.other Animal immunology en_ZA
dc.subject.other Animal parasitology en_ZA
dc.subject.other Animal pathology en_ZA
dc.title IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2008 Marillier et al; licensee BioMed Central Ltd en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Immunology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Marillier, R., Michels, C., Smith, E., Fick, L., Leeto, M., Dewals, B., ... Brombacher, F. (2008). IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. <i>BMC Immunology</i>, http://hdl.handle.net/11427/14469 en_ZA
dc.identifier.chicagocitation Marillier, Reece, Chesney Michels, Elizabeth Smith, Lizette Fick, Mosiuoa Leeto, Benjamin Dewals, William Horsnell, and Frank Brombacher "IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections." <i>BMC Immunology</i> (2008) http://hdl.handle.net/11427/14469 en_ZA
dc.identifier.vancouvercitation Marillier R, Michels C, Smith E, Fick L, Leeto M, Dewals B, et al. IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunology. 2008; http://hdl.handle.net/11427/14469. en_ZA
dc.identifier.ris TY - Journal Article AU - Marillier, Reece AU - Michels, Chesney AU - Smith, Elizabeth AU - Fick, Lizette AU - Leeto, Mosiuoa AU - Dewals, Benjamin AU - Horsnell, William AU - Brombacher, Frank AB - BACKGROUND: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is associated with TH2 immune responses, which in helminth infections are controlled primarily by IL-13, and also IL-4. In the study presented here we examine the goblet cell hyperplasic response to three experimental parasitic helminth infections; namely Nippostrongylus brasiliensis, Syphacia obvelata and Schistosoma mansoni. RESULTS: As expected N. brasiliensis infection induced a strong goblet cell hyperplasia dependent on IL-4/IL-13/IL-4Ralpha expression. In contrast, and despite previously published transiently elevated IL-4/IL-13 levels, S. obvelata infections did not increase goblet cell hyperplasia in the colon. Furthermore, induction of goblet cell hyperplasia in response to S. mansoni eggs traversing the intestine was equivalent between BALB/c, IL-4/IL-13-/- and IL-4Ralpha-/- mice. CONCLUSION: Together these data demonstrate that intestinal goblet cell hyperplasia can be independent of TH2 immune responses associated with parasitic helminth infections. DA - 2008 DB - OpenUCT DO - 10.1186/1471-2172-9-11 DP - University of Cape Town J1 - BMC Immunology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections TI - IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections UR - http://hdl.handle.net/11427/14469 ER - en_ZA


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