Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans

 

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dc.contributor.author Singh, Dinesh en_ZA
dc.contributor.author Joska, John en_ZA
dc.contributor.author Goodkin, Karl en_ZA
dc.contributor.author Lopez, Enrique en_ZA
dc.contributor.author Myer, Landon en_ZA
dc.contributor.author Paul, Robert en_ZA
dc.contributor.author John, Sally en_ZA
dc.contributor.author Sunpath, Henry en_ZA
dc.date.accessioned 2015-10-28T06:54:28Z
dc.date.available 2015-10-28T06:54:28Z
dc.date.issued 2010 en_ZA
dc.identifier.citation Singh, D., Joska, J. A., Goodkin, K., Lopez, E., Myer, L., Paul, R. H., ... & Sunpath, H. (2010). Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans. BMC research notes, 3(1), 28. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14438
dc.identifier.uri http://dx.doi.org/10.1186/1756-0500-3-28
dc.description.abstract BACKGROUND:There is an urgent need to more accurately diagnose HIV-associated neurocognitive disorder (HAND) in Africa. Rapid screening tests for HIV-associated dementia are of limited utility due to variable sensitivity and specificity. The use of selected neuropsychological tests is more appropriate, but norms for HIV seronegative people are not readily available for sub-Saharan African populations. We sought to derive normative scores for two commonly used neuropsychological tests that generate four test scores -- namely the Trail-Making Test (Parts A and B) and the Digit Span Test [Forward (DSF) and Backward (DSB)]. To assess memory and recall, we used the memory item of the International HIV Dementia Scale (IHDS).FINDINGS:One hundred and ten HIV seronegative participants were assessed at McCord Hospital, Durban, South Africa between March 3rd and October 31st, 2008. We excluded people with major depressive disorder, substance use abuse and dependence and head injuries (with or without loss of consciousness). All the participants in this study were African and predominantly female with an average age of 28.5 years and 10 years of education. Age and gender influenced neuropsychological functioning, with older people performing worse. The effect of gender was not uniform across all the tests. CONCLUSION: These two neuropsychological tests can be administered with the IHDS in busy antiretroviral clinics. Their performance can be measured against these norms to more accurately diagnose the spectrum and progression of HAND. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source BMC Research Notes en_ZA
dc.source.uri http://www.biomedcentral.com/bmcresnotes/ en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Dementia en_ZA
dc.subject.other Neuropsychological tests en_ZA
dc.title Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2010 Singh et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Child and Adolescent Psychiatry en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Singh, D., Joska, J., Goodkin, K., Lopez, E., Myer, L., Paul, R., ... Sunpath, H. (2010). Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans. <i>BMC Research Notes</i>, http://hdl.handle.net/11427/14438 en_ZA
dc.identifier.chicagocitation Singh, Dinesh, John Joska, Karl Goodkin, Enrique Lopez, Landon Myer, Robert Paul, Sally John, and Henry Sunpath "Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans." <i>BMC Research Notes</i> (2010) http://hdl.handle.net/11427/14438 en_ZA
dc.identifier.vancouvercitation Singh D, Joska J, Goodkin K, Lopez E, Myer L, Paul R, et al. Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans. BMC Research Notes. 2010; http://hdl.handle.net/11427/14438. en_ZA
dc.identifier.ris TY - Journal Article AU - Singh, Dinesh AU - Joska, John AU - Goodkin, Karl AU - Lopez, Enrique AU - Myer, Landon AU - Paul, Robert AU - John, Sally AU - Sunpath, Henry AB - BACKGROUND:There is an urgent need to more accurately diagnose HIV-associated neurocognitive disorder (HAND) in Africa. Rapid screening tests for HIV-associated dementia are of limited utility due to variable sensitivity and specificity. The use of selected neuropsychological tests is more appropriate, but norms for HIV seronegative people are not readily available for sub-Saharan African populations. We sought to derive normative scores for two commonly used neuropsychological tests that generate four test scores -- namely the Trail-Making Test (Parts A and B) and the Digit Span Test [Forward (DSF) and Backward (DSB)]. To assess memory and recall, we used the memory item of the International HIV Dementia Scale (IHDS).FINDINGS:One hundred and ten HIV seronegative participants were assessed at McCord Hospital, Durban, South Africa between March 3rd and October 31st, 2008. We excluded people with major depressive disorder, substance use abuse and dependence and head injuries (with or without loss of consciousness). All the participants in this study were African and predominantly female with an average age of 28.5 years and 10 years of education. Age and gender influenced neuropsychological functioning, with older people performing worse. The effect of gender was not uniform across all the tests. CONCLUSION: These two neuropsychological tests can be administered with the IHDS in busy antiretroviral clinics. Their performance can be measured against these norms to more accurately diagnose the spectrum and progression of HAND. DA - 2010 DB - OpenUCT DO - 10.1186/1756-0500-3-28 DP - University of Cape Town J1 - BMC Research Notes LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans TI - Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans UR - http://hdl.handle.net/11427/14438 ER - en_ZA


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