Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe

 

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dc.contributor.author Chin'ombe, Nyasha en_ZA
dc.contributor.author Chavhunduka, Evans en_ZA
dc.contributor.author Matarira, Hilda en_ZA
dc.date.accessioned 2015-10-28T06:45:32Z
dc.date.available 2015-10-28T06:45:32Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Chin'ombe, N., Chavhunduka, E., & Matarira, H. T. (2009). Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe. Infect Agent Cancer, 4, 15. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14422
dc.identifier.uri http://dx.doi.org/10.1186/1750-9378-4-15
dc.description.abstract BACKGROUND:Primary hepatocellular carcinoma (PHC) is one of the most common cancers in Zimbabwe. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are suspected to play a major role in causing this cancer. The objective of this study was to determine the seroprevalence of HBV and HCV in PHC at Parirenyatwa Referral Hospital in Zimbabwe. We evaluated the serological markers of the two viruses in patients with PHC using commercially available enzyme-linked immunosorbent kits. RESULTS: Out of the 60 patients with PHC, 48.3% were seropositive for HBV and 20.0% were seropositive for HCV. Co-infection by HCV and HBV was found in 8% of the patients. Only 13.3% of the health controls (blood donors) were positive for HBV. All the controls were negative for HCV. CONCLUSION: The high seropositivity of HBV and HCV in PHC in Zimbabwe suggested that the two viruses were a major cause of the cancer. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Infectious Agents and Cancer en_ZA
dc.source.uri http://www.infectagentscancer.com en_ZA
dc.subject.other Primary hepatocellular carcinoma en_ZA
dc.subject.other Hepatitis B virus en_ZA
dc.subject.other Hepatitis B virus en_ZA
dc.title Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2009 Chin'ombe et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Virology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Chin'ombe, N., Chavhunduka, E., & Matarira, H. (2009). Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe. <i>Infectious Agents and Cancer</i>, http://hdl.handle.net/11427/14422 en_ZA
dc.identifier.chicagocitation Chin'ombe, Nyasha, Evans Chavhunduka, and Hilda Matarira "Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe." <i>Infectious Agents and Cancer</i> (2009) http://hdl.handle.net/11427/14422 en_ZA
dc.identifier.vancouvercitation Chin'ombe N, Chavhunduka E, Matarira H. Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe. Infectious Agents and Cancer. 2009; http://hdl.handle.net/11427/14422. en_ZA
dc.identifier.ris TY - Journal Article AU - Chin'ombe, Nyasha AU - Chavhunduka, Evans AU - Matarira, Hilda AB - BACKGROUND:Primary hepatocellular carcinoma (PHC) is one of the most common cancers in Zimbabwe. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are suspected to play a major role in causing this cancer. The objective of this study was to determine the seroprevalence of HBV and HCV in PHC at Parirenyatwa Referral Hospital in Zimbabwe. We evaluated the serological markers of the two viruses in patients with PHC using commercially available enzyme-linked immunosorbent kits. RESULTS: Out of the 60 patients with PHC, 48.3% were seropositive for HBV and 20.0% were seropositive for HCV. Co-infection by HCV and HBV was found in 8% of the patients. Only 13.3% of the health controls (blood donors) were positive for HBV. All the controls were negative for HCV. CONCLUSION: The high seropositivity of HBV and HCV in PHC in Zimbabwe suggested that the two viruses were a major cause of the cancer. DA - 2009 DB - OpenUCT DO - 10.1186/1750-9378-4-15 DP - University of Cape Town J1 - Infectious Agents and Cancer LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe TI - Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe UR - http://hdl.handle.net/11427/14422 ER - en_ZA


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