The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study

 

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dc.contributor.author Dalvie, Mohamed en_ZA
dc.contributor.author Myers, Jonathan en_ZA
dc.date.accessioned 2015-10-12T10:54:44Z
dc.date.available 2015-10-12T10:54:44Z
dc.date.issued 2006 en_ZA
dc.identifier.citation Dalvie, M. A., & Myers, J. E. (2005). The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. J Occup Med Toxicol, 1(6). en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14183
dc.identifier.uri http://dx.doi.org/10.1186/1745-6673-1-21
dc.description.abstract BACKGROUND:The utility of blood reproductive endocrine biomarkers for assessing or estimating semen quality was explored. METHODS: A cross-sectional study of 47 DDT exposed malaria vector control workers was performed. Tests included blood basal and post gonadotrophin releasing hormone (GnRH), lutenizing hormone (LH), follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), estradiol (E2) and inhibin; a questionnaire (demographics and general medical history); a physical examination and semen analysis. Semen parameters were determined using either/or or both WHO or the strict Tygerberg criteria. Relationships between semen parameters and endocrine measures were adjusted for age, duration of abstinence before sampling, presence of physical abnormalities and fever in the last two months. All relationships between specific endocrine hormones were adjusted for age and basal SHBG. RESULTS: Multiple logistic regression showed a consistent positive relationship (prevalence odds ratio (POR) = 8.2, CI:1.4-49.2) between low basal inhibin (<100 pg/ml) and low semen count (< 40 million) and density (< 20 million/ml); consistent positive, but weaker relationships (1> POR < 2) between abnormally low semen count as well as density and baseline and post GnRH FSH; and positive relationships (POR = 37, CI:2-655) between the prevalence of high basal estradiol (> 50 pg/ml) and abnormal morphology (proportion < 5%) and low motility (proportion <50%). Most of the expected physiological relationships between specific endocrines were significant. CONCLUSION: The study has demonstrated that low basal inhibin, elevated basal FSH and high basal E2 can serve as markers of impaired semen quality. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Journal of Occupational Medicine and Toxicology en_ZA
dc.source.uri http://www.occup-med.com en_ZA
dc.subject.other Occupational and Environmental Health en_ZA
dc.title The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study en_ZA
dc.type Journal Article en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Women's Health Research Unit en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License