Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease

 

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dc.contributor.advisor Opie, Lionel H en_ZA
dc.contributor.advisor Engel, Mark E en_ZA
dc.contributor.author Mothilal, Shikar en_ZA
dc.date.accessioned 2015-08-27T12:30:00Z
dc.date.available 2015-08-27T12:30:00Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Mothilal, S. 2015. Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/13785
dc.description.abstract In the management of coronary artery disease (CAD) most advances have concerned improvements in catheter-based interventional techniques and complex pharmacotherapy, with an emphasis on time, which unfortunately, cannot always achieved. However, simple measures with reassuring benefit that can be performed even by non-cardiologists have been largely overlooked, or understated. These include limiting reperfusion injury by remote ischaemic conditioning (RIPC), a powerful protective mechanism that can be elicited by the transient occlusion of blood flow to a limb with a blood pressure cuff. More controversially, glucose-insulin-potassium (GIK) therapy in early ST elevation myocardial infarction (STEMI) has the potential to improve outcomes especially when timely restoration of vessel patency is difficult to achieve. This systematic review will evaluate the role of these therapies as adjuncts to revascularisation for treating coronary artery disease either electively or during an acute coronary syndrome. Objectives: To determine if RIPC or GIK therapy for CAD leads to reduced mortality (primary objective), infarct size, cardiac enzyme release or major adverse cardiac and cerebral events (MACCE) and to identify adverse effects associated with RIPC or GIK (secondary objectives). en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Cardiology en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MMed en_ZA
uct.type.filetype Text
uct.type.filetype Image


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