New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments

 

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dc.contributor.advisor Franzidis, Jean-Paul en_ZA
dc.contributor.advisor Buffler, Andy en_ZA
dc.contributor.advisor Cole, Katie en_ZA
dc.contributor.author Liu, Cong en_ZA
dc.date.accessioned 2015-08-12T04:04:24Z
dc.date.available 2015-08-12T04:04:24Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Liu, C. 2015. New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/13709
dc.description.abstract Positron emission particle tracking (PEPT) is a non-invasive technique for studying the flow of particulate systems within industrial equipment. The technique tracks a tracer particle labelled with a positron emitting radionuclide moving within the field-of-view of a positron emission tomography (PET) scanner. Two important components of the technique are a PET camera and PEPT tracers, which are particle tracers labelled with a positron emitting radionuclide. Currently, the majority of PEPT tracers are made with 68Ga or 18F. However, the relatively short half-life of these two radionuclides limits the application of PEPT to a maximum of 3 hours of experimental time. 64Cu is a potential candidate for PEPT tracer fabrication due to its relatively long half-life (12.7 h) which could extend the experimental running time of PEPT experiments to two uninterrupted days. The objective of the research described in this thesis was to develop a technique for radiolabelling tracers with 64Cu, and to test their efficacy in PEPT experiment. The work was conducted at Radionuclide Production Department, iThemba LABS near Cape Town, where high purity 64Cu was obtained by a two stages separation method using ion exchange chromatography. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemical Engineering en_ZA
dc.title New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Engineering and the Built Environment
dc.publisher.department Department of Chemical Engineering en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc (Eng) en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Liu, C. (2015). <i>New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments</i>. (Thesis). University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Chemical Engineering. Retrieved from http://hdl.handle.net/11427/13709 en_ZA
dc.identifier.chicagocitation Liu, Cong. <i>"New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments."</i> Thesis., University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Chemical Engineering, 2015. http://hdl.handle.net/11427/13709 en_ZA
dc.identifier.vancouvercitation Liu C. New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments. [Thesis]. University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Chemical Engineering, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13709 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Liu, Cong AB - Positron emission particle tracking (PEPT) is a non-invasive technique for studying the flow of particulate systems within industrial equipment. The technique tracks a tracer particle labelled with a positron emitting radionuclide moving within the field-of-view of a positron emission tomography (PET) scanner. Two important components of the technique are a PET camera and PEPT tracers, which are particle tracers labelled with a positron emitting radionuclide. Currently, the majority of PEPT tracers are made with 68Ga or 18F. However, the relatively short half-life of these two radionuclides limits the application of PEPT to a maximum of 3 hours of experimental time. 64Cu is a potential candidate for PEPT tracer fabrication due to its relatively long half-life (12.7 h) which could extend the experimental running time of PEPT experiments to two uninterrupted days. The objective of the research described in this thesis was to develop a technique for radiolabelling tracers with 64Cu, and to test their efficacy in PEPT experiment. The work was conducted at Radionuclide Production Department, iThemba LABS near Cape Town, where high purity 64Cu was obtained by a two stages separation method using ion exchange chromatography. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments TI - New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments UR - http://hdl.handle.net/11427/13709 ER - en_ZA


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