Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

 

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dc.contributor.author White, Nicholas J
dc.contributor.author Ashley, Elizabeth A
dc.contributor.author Recht, Judith
dc.contributor.author Delves, Michael J
dc.contributor.author Ruecker, Andrea
dc.contributor.author Smithuis, Frank M
dc.contributor.author Eziefula, Alice C
dc.contributor.author Bousema, Teun
dc.contributor.author Drakeley, Chris
dc.contributor.author Chotivanich, Kesinee
dc.contributor.author Imwong, Mallika
dc.contributor.author Pukrittayakamee, Sasithon
dc.contributor.author Prachumsri, Jetsumon
dc.contributor.author Chu, Cindy
dc.contributor.author Andolina, Chiara
dc.contributor.author Bancone, Germana
dc.contributor.author Hien, Tran T
dc.contributor.author Mayxay, Mayfong
dc.contributor.author Taylor, Walter R
dc.contributor.author von Seidlein, Lorenz
dc.contributor.author Price, Ric N
dc.contributor.author Barnes, Karen I
dc.contributor.author Djimdé, Abdoulaye
dc.contributor.author ter Kuile, Feiko
dc.contributor.author Gosling, Roly
dc.contributor.author Chen, Ingrid
dc.contributor.author Dhorda, Mehul J
dc.contributor.author Stepniewska, Kasia
dc.contributor.author Guérin, Philippe
dc.contributor.author Woodrow, Charles J
dc.contributor.author Dondorp, Arjen M
dc.contributor.author Day, Nicholas P
dc.contributor.author Nosten, Francois H
dc.date.accessioned 2015-07-30T03:57:50Z
dc.date.available 2015-07-30T03:57:50Z
dc.date.issued 2014-12-09
dc.identifier.citation White, N. J., Ashley, E. A., Recht, J., Delves, M. J., Ruecker, A., Smithuis, F. M., ... & Nosten, F. H. (2014). Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malaria journal, 13(1), 483.
dc.identifier.uri http://hdl.handle.net/11427/13599
dc.identifier.uri http://dx.doi.org/10.1186/1475-2875-13-483
dc.description.abstract Abstract Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License *
dc.rights.uri http://creativecommons.org/licenses/by/4.0 *
dc.source Malaria Journal en_ZA
dc.source.uri http://www.malariajournal.com
dc.title Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
dc.type Journal Article en_ZA
dc.date.updated 2015-05-05T18:01:21Z
dc.language.rfc3066 en
dc.rights.holder White et al.; licensee BioMed Central.
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
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uct.type.filetype Text
uct.type.filetype Image


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License