Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects

 

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dc.contributor.advisor Rodgers, Allen en_ZA
dc.contributor.author Bungane, Ntombovuyo en_ZA
dc.date.accessioned 2015-05-06T07:18:11Z
dc.date.available 2015-05-06T07:18:11Z
dc.date.issued 2008 en_ZA
dc.identifier.citation Bungane, N. 2008. Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/12750
dc.description Includes bibliographical references. en_ZA
dc.description.abstract In South Africa, the incidence of urolithiasis in the white population occurs to the same extent as in other western societies. However, in the black population, this disease is extremely rare. Differences in the gastrointestinal and renal handling of several lithogenic and antilithogenic agents in the two ethnic groups have been reported, but the rarity of kidney stone disease in the black group remains a riddle. The studies described in this thesis were undertaken to address aspects of this phenomenon. Carbohydrate and oxalate-containing dietary agents were identified as being of interest since surveys have paradoxically demonstrated that the consumption of these potentially lithogenic substances is significantly higher in the black group. The carbohydrates selected for study were glucose, sorbitol and xylitol, while the oxalatecontaining agents were rhubarb, spinach and an aqueous solution of sodium oxalate itself. Finally, taurine, which has been shown to reduce urinary glycolate and oxalate in animal models, was also selected for investigation in the two population groups. In all studies, similar protocols were adopted. These were approved by the Research and Ethics Committee of the University of Cape Town. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Bungane, N. (2008). <i>Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12750 en_ZA
dc.identifier.chicagocitation Bungane, Ntombovuyo. <i>"Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008. http://hdl.handle.net/11427/12750 en_ZA
dc.identifier.vancouvercitation Bungane N. Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12750 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Bungane, Ntombovuyo AB - In South Africa, the incidence of urolithiasis in the white population occurs to the same extent as in other western societies. However, in the black population, this disease is extremely rare. Differences in the gastrointestinal and renal handling of several lithogenic and antilithogenic agents in the two ethnic groups have been reported, but the rarity of kidney stone disease in the black group remains a riddle. The studies described in this thesis were undertaken to address aspects of this phenomenon. Carbohydrate and oxalate-containing dietary agents were identified as being of interest since surveys have paradoxically demonstrated that the consumption of these potentially lithogenic substances is significantly higher in the black group. The carbohydrates selected for study were glucose, sorbitol and xylitol, while the oxalatecontaining agents were rhubarb, spinach and an aqueous solution of sodium oxalate itself. Finally, taurine, which has been shown to reduce urinary glycolate and oxalate in animal models, was also selected for investigation in the two population groups. In all studies, similar protocols were adopted. These were approved by the Research and Ethics Committee of the University of Cape Town. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects TI - Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects UR - http://hdl.handle.net/11427/12750 ER - en_ZA


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