Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease

 

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dc.contributor.advisor Bateman, Eric D en_ZA
dc.contributor.author Allwood, Brian William en_ZA
dc.date.accessioned 2015-05-04T07:07:44Z
dc.date.available 2015-05-04T07:07:44Z
dc.date.issued 2014 en_ZA
dc.identifier.citation Allwood, B. 2014. Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/12715
dc.description Includes bibliographical references. en_ZA
dc.description.abstract Epidemiological studies in populations with a high burden of pulmonary tuberculosis (PTB), including the Burden of Obstructive Lung Disease (BOLD) survey performed in Cape Town, South Africa in 2005, have suggested an association between PTB and the development of chronic airflow obstruction (CAO). The nature of this association and mechanisms responsible for CAO has not been previously studied, but likely includes: airway narrowing (from bronchiolitis, bronchiectasis or persistent low-grade inflammation associated with healed PTB); and reduced lung elastic recoil from coexistent emphysema. The present study investigated the structure and function of the lung in subjects with tuberculosis-associated obstructive pulmonary disease (TOPD) identified in BOLD 2005, and aspects of its natural history and response to treatment. It also examined the diagnostic performance of the standardised and internationally accepted BOLD method for estimating the prevalence of COPD in community-based surveys, with specific reference to misdiagnosis that might lead to overestimates of prevalence. en_ZA
dc.language.iso eng en_ZA
dc.title Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Doctoral en_ZA
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image


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