Supramolecular modification of selected antiretroviral drugs

 

Show simple item record

dc.contributor.advisor Caira, Mino R en_ZA
dc.contributor.advisor Bourne, Susan en_ZA
dc.contributor.author Engel, Emile Richard en_ZA
dc.date.accessioned 2015-04-02T14:18:25Z
dc.date.available 2015-04-02T14:18:25Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Engel, E. 2011. Supramolecular modification of selected antiretroviral drugs. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/12675
dc.description Includes bibliographical references. en_ZA
dc.description.abstract A number of antiretroviral drugs that are currently in use for anti-HIV therapy have extremely poor aqueous solubility. This, along with the fact that many of these pharmaceutical compounds possess potential hydrogen bond donor and acceptor functionalities, makes them ideal candidates for attempted supramolecular derivatisation. The primary objective of this study was to carry out cocrystal screening and attempt cyclodextrin complexation with nevirapine, efavirenz, lamivudine and zidovudine, with a view to identifying and isolating new solid forms of these drugs. Any new forms were to be characterised by a variety of analytical techniques, including thermal, spectroscopic and X-ray analysis and, where possible, such derivatives would be tested for any enhancements of drug solubility. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Supramolecular modification of selected antiretroviral drugs en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image


Files in this item

This item appears in the following Collection(s)

Show simple item record