Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study

 

Show simple item record

dc.contributor.advisor Fazakerley, G V en_ZA
dc.contributor.author Koch, Klaus R en_ZA
dc.date.accessioned 2015-03-16T10:31:07Z
dc.date.available 2015-03-16T10:31:07Z
dc.date.issued 1979 en_ZA
dc.identifier.citation Koch, K. 1979. Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/12618
dc.description Bibliography: p. 181-184. en_ZA
dc.description.abstract The aqueous solution conformation of SAH and SAM has been investigated using lanthanide probes. SAH at pH 7.0 interacts normally with lanthanide aquo ions and lanthanide-EDTA complexes via coordination at the carboxyl group. The conformation of the homocysteine fragment is found to, be extended but bent back towards the adenine base. SAM does not interact with lanthanide aquo ions in the pH region 2-7. It does form complexes with lanthanide-EDTA species via an ion-pairing mechanism rather than direct coordination. In addition to lanthanide probes, 250 MHz 1H n.m.r. spectra yielded vicinal JHH coupling constants from which the ribose conformation in both SAM and SAH could be more accurately determined. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Inorganic Chemistry en_ZA
dc.title Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Koch, K. R. (1979). <i>Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12618 en_ZA
dc.identifier.chicagocitation Koch, Klaus R. <i>"Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1979. http://hdl.handle.net/11427/12618 en_ZA
dc.identifier.vancouvercitation Koch KR. Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1979 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12618 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Koch, Klaus R AB - The aqueous solution conformation of SAH and SAM has been investigated using lanthanide probes. SAH at pH 7.0 interacts normally with lanthanide aquo ions and lanthanide-EDTA complexes via coordination at the carboxyl group. The conformation of the homocysteine fragment is found to, be extended but bent back towards the adenine base. SAM does not interact with lanthanide aquo ions in the pH region 2-7. It does form complexes with lanthanide-EDTA species via an ion-pairing mechanism rather than direct coordination. In addition to lanthanide probes, 250 MHz 1H n.m.r. spectra yielded vicinal JHH coupling constants from which the ribose conformation in both SAM and SAH could be more accurately determined. DA - 1979 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1979 T1 - Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study TI - Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study UR - http://hdl.handle.net/11427/12618 ER - en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record