A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?
Master Thesis
2009
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University of Cape Town
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Abstract
Living donor liver transplantation (LDLT) is now well established and performed on a routine basis in many major centres around the world. LDLT is feasible because of the capacity of both the remnant donor liver and the transplanted partial liver to undergo liver regeneration. However it has been demonstrated that liver regeneration in the recipient is rapid, whereas restoration of liver mass in the donor is delayed. This discrepancy in the rate of regeneration could be due to the presence of hepatotrophic factors and the use of immunosuppression in the recipient. The aims of the studies were to determine if hepatotrophic factors and immunosuppression (Cyclosporine) could modify the restoration of the liver mass after partial hepatectomy in rats.
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Includes bibliographical references (leaves 54-62).
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Ibirogba, S. 2009. A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?. University of Cape Town.