Hyperglobulinaemia in the portacaval shunted rat : an experimental study.

 

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dc.contributor.advisor Meyers, O L en_ZA
dc.contributor.author Keraan, Mogamat Mustapha en_ZA
dc.date.accessioned 2015-01-27T10:00:21Z
dc.date.available 2015-01-27T10:00:21Z
dc.date.issued 1975 en_ZA
dc.identifier.citation Keraan, M. 1975. Hyperglobulinaemia in the portacaval shunted rat : an experimental study. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/12324
dc.description Includes bibliographical references. en_ZA
dc.description.abstract The construction of a portacaval shunt in the rat is followed by a series of characteristic phenomena : weight loss, hypo-albuminaemia, hyperglobulinaemia and an increase in the circulating antibacterial antibody levels to endogenous bowel micro-organisms. The weight loss is characterised by several weeks of decreasing weight followed by a slow progressive reversal to normality and it has its origins in postoperative anorexia. The hypo-albuminaemia to some extent parallels the weight loss but never reaches the same magnitude and it too is likely to be closely associated with anorexia. The hyperglobulinaemia which is polyclonal embraces a rise in all three major immunoglobulin classes of the rat. Evidence is presented that links this polyclonal hyperglobulinaemia to enhanced antibacterial antibodies which increase following the portacaval shunt. The shunt is believed to effectively separate the reticulo-endothelial system of the liver from the portal circulation thus allowing unlimited and constant access of antigenic material from the bowel to immunocompetent cells. Evidence is also advanced that such material from microorganisms may also stimulate other immune reactions. Similar studies in the pig are also presented and the close parallel with chronic human liver disease led to the development of an hypothesis that portal shunting of blood is the cause of hyperglobulinaemia in man. The rat is suggested as a suitable model for the experimental reproduction of human hyperglobulinaemia. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Zoology en_ZA
dc.title Hyperglobulinaemia in the portacaval shunted rat : an experimental study. en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Biological Sciences en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Keraan, M. M. (1975). <i>Hyperglobulinaemia in the portacaval shunted rat : an experimental study</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Biological Sciences. Retrieved from http://hdl.handle.net/11427/12324 en_ZA
dc.identifier.chicagocitation Keraan, Mogamat Mustapha. <i>"Hyperglobulinaemia in the portacaval shunted rat : an experimental study."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 1975. http://hdl.handle.net/11427/12324 en_ZA
dc.identifier.vancouvercitation Keraan MM. Hyperglobulinaemia in the portacaval shunted rat : an experimental study. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 1975 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12324 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Keraan, Mogamat Mustapha AB - The construction of a portacaval shunt in the rat is followed by a series of characteristic phenomena : weight loss, hypo-albuminaemia, hyperglobulinaemia and an increase in the circulating antibacterial antibody levels to endogenous bowel micro-organisms. The weight loss is characterised by several weeks of decreasing weight followed by a slow progressive reversal to normality and it has its origins in postoperative anorexia. The hypo-albuminaemia to some extent parallels the weight loss but never reaches the same magnitude and it too is likely to be closely associated with anorexia. The hyperglobulinaemia which is polyclonal embraces a rise in all three major immunoglobulin classes of the rat. Evidence is presented that links this polyclonal hyperglobulinaemia to enhanced antibacterial antibodies which increase following the portacaval shunt. The shunt is believed to effectively separate the reticulo-endothelial system of the liver from the portal circulation thus allowing unlimited and constant access of antigenic material from the bowel to immunocompetent cells. Evidence is also advanced that such material from microorganisms may also stimulate other immune reactions. Similar studies in the pig are also presented and the close parallel with chronic human liver disease led to the development of an hypothesis that portal shunting of blood is the cause of hyperglobulinaemia in man. The rat is suggested as a suitable model for the experimental reproduction of human hyperglobulinaemia. DA - 1975 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1975 T1 - Hyperglobulinaemia in the portacaval shunted rat : an experimental study TI - Hyperglobulinaemia in the portacaval shunted rat : an experimental study UR - http://hdl.handle.net/11427/12324 ER - en_ZA


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